ZP4

Description		zona pellucida glycoprotein 4
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Plasma Membrane Membrane Extracellular Matrix Egg Coat
	Molecular Function	Protein Binding Acrosin Binding Structural Constituent Of Egg Coat Identical Protein Binding
	Biological Process	Positive Regulation Of Humoral Immune Response Single Fertilization Binding Of Sperm To Zona Pellucida Positive Regulation Of T Cell Proliferation Prevention Of Polyspermy Acrosomal Vesicle Exocytosis Positive Regulation Of Acrosome Reaction Negative Regulation Of Binding Of Sperm To Zona Pellucida
Pathways		Interaction With Cumulus Cells And The Zona Pellucida
Drugs
Diseases
GWAS		C-peptide levels in type I diabetes ( 29404672) Hypertension ( 17554300) Metabolite levels ( 23823483) Non-alcoholic fatty liver disease histology (AST) ( 20708005) Refractive error ( 32231278) Stimulated C-peptide levels in type I diabetes ( 29404672)
Interacting Genes		1 interacting genes: FURIN
Entrez ID		57829
HPRD ID		18363
Ensembl ID		ENSG00000116996
Uniprot IDs		Q12836
PDB IDs
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Nerve Growth Factor Production Golgi Apparatus Subcompartment Regulation Of Nerve Growth Factor Production Negative Regulation Of Low-density Lipoprotein Particle Receptor Catabolic Process Dibasic Protein Processing Zymogen Inhibition Nerve Growth Factor Production Negative Regulation Of Neurotrophin Production Negative Regulation Of Receptor Catabolic Process Viral Translation Viral Life Cycle Cytokine Precursor Processing Nerve Growth Factor Binding Regulation Of Low-density Lipoprotein Particle Receptor Catabolic Process Negative Regulation Of Transforming Growth Factor Beta1 Production Heparan Sulfate Binding Signal Peptide Processing Negative Regulation Of Transforming Growth Factor Beta Production Positive Regulation Of Viral Entry Into Host Cell Positive Regulation Of Membrane Protein Ectodomain Proteolysis Trans-Golgi Network Transport Vesicle Endopeptidase Activator Activity Regulation Of Viral Entry Into Host Cell Negative Regulation Of Protein Processing Blastocyst Formation Peptide Biosynthetic Process Negative Regulation Of Protein Maturation Positive Regulation Of Viral Life Cycle Viral Protein Processing Peptide Binding Amyloid Fibril Formation Regulation Of Membrane Protein Ectodomain Proteolysis Negative Regulation Of Inflammatory Response To Antigenic Stimulus Collagen Catabolic Process Protein-containing Complex Remodeling Zymogen Activation Peptide Hormone Processing Plasma Lipoprotein Particle Remodeling Signaling Receptor Ligand Precursor Processing Organelle Membrane Extracellular Matrix Disassembly Regulation Of Protein Processing Peptide Metabolic Process Positive Regulation Of Viral Process Regulation Of Protein Maturation Regulation Of Cholesterol Transport Collagen Metabolic Process Serine-type Endopeptidase Inhibitor Activity Endopeptidase Activity Golgi Lumen
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