ZP4

Gene Name		zona pellucida glycoprotein 4
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Proteinaceous Extracellular Matrix Plasma Membrane Integral Component Of Membrane
	Molecular Function	Signal Transducer Activity Acrosin Binding
	Biological Process	Positive Regulation Of Humoral Immune Response Single Fertilization Binding Of Sperm To Zona Pellucida Protein Kinase A Signaling Multicellular Organism Reproduction Intracellular Signal Transduction Positive Regulation Of T Cell Proliferation Positive Regulation Of Protein Kinase Activity Acrosomal Vesicle Exocytosis Protein Kinase C Signaling Positive Regulation Of Acrosome Reaction Negative Regulation Of Binding Of Sperm To Zona Pellucida
Pathways		Interaction With The Zona Pellucida Fertilization
Drugs
Diseases
GWAS		Hypertension ( 17554300) Non-alcoholic fatty liver disease histology (AST) ( 20708005)
Protein-protein Interactions		1 interactors: FURIN
Entrez ID		57829
HPRD ID		18363
Ensembl ID
Uniprot IDs		Q12836
PDB IDs
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Low-density Lipoprotein Particle Receptor Catabolic Process Nerve Growth Factor Production Negative Regulation Of Transforming Growth Factor Beta1 Production Negative Regulation Of Receptor Catabolic Process Nerve Growth Factor Processing Regulation Of Low-density Lipoprotein Particle Receptor Catabolic Process Negative Regulation Of Transforming Growth Factor Beta Production Viral Protein Processing Positive Regulation Of Membrane Protein Ectodomain Proteolysis Peptidyl-glutamic Acid Carboxylation Signal Peptide Processing Virion Assembly Peptide Biosynthetic Process Peptide Hormone Processing Collagen Catabolic Process Negative Regulation Of Cellular Protein Catabolic Process Collagen Metabolic Process Multicellular Organismal Macromolecule Metabolic Process Multicellular Organismal Metabolic Process Extracellular Matrix Disassembly Negative Regulation Of Protein Catabolic Process Notch Signaling Pathway Transforming Growth Factor Beta Receptor Signaling Pathway Peptide Metabolic Process Hormone Metabolic Process Cellular Response To Transforming Growth Factor Beta Stimulus Viral Life Cycle Response To Transforming Growth Factor Beta Post-translational Protein Modification Pathogenesis Negative Regulation Of Cytokine Production Neurotrophin TRK Receptor Signaling Pathway Positive Regulation Of Protein Catabolic Process Neurotrophin Signaling Pathway Protein Processing Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Cellular Amide Metabolic Process Negative Regulation Of Endopeptidase Activity Regulation Of Hormone Levels Negative Regulation Of Peptidase Activity Positive Regulation Of Proteolysis Negative Regulation Of Proteolysis Negative Regulation Of Protein Processing Extracellular Matrix Organization Extracellular Structure Organization Regulation Of Endopeptidase Activity Regulation Of Protein Catabolic Process Negative Regulation Of Hydrolase Activity Regulation Of Protein Processing Regulation Of Peptidase Activity
Tagcloud ?		bird coat deglycosylated disc egg eggs enzymatically follicles germinal glycoproteins glycosylated granulosa heavily immature immunohistological maturing oocyte ovulated pellucida penetration preferential sperm surrounded yellow zona zp2 zp3 zpd