ZFYVE28

Name	zinc finger FYVE-type containing 28
Structure
Interactors	1 interactors: PRNP
GO Annotations	Cellular Component	Cytoplasm Endosome Cytosol Membrane Early Endosome Membrane
	Molecular Function	Protein Binding Zinc Ion Binding Phosphatidylinositol-3-phosphate Binding Metal Ion Binding
	Biological Process	Negative Regulation Of Epidermal Growth Factor-activated Receptor Activity Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway
GWAS	Influenza A (H1N1) severity ( 26379185 ) Longevity ( 26912274 ) Metabolite levels ( 23823483 ) Nicotine dependence and major depression (severity of comorbidity) ( 30287806 ) Nicotine dependence symptom count ( 25555482 ) Schizophrenia ( 23212062 ) Serum immune biomarker levels ( 32066700 ) Tourette syndrome ( 30818990 )
Entrez ID	57732
HPRD ID	11701
Ensembl ID	ENSG00000159733
Uniprot IDs	Q9HCC9
PDB IDs	9F42 9F43 9F44 9F45
GO Terms Enriched among Interactors ?	ATP-dependent Protein Binding Negative Regulation Of Calcineurin-NFAT Signaling Cascade Positive Regulation Of Glutamate Receptor Signaling Pathway Inclusion Body Regulation Of Calcium Ion Import Across Plasma Membrane Neuron Projection Maintenance Negative Regulation Of Interleukin-17 Production Negative Regulation Of Dendritic Spine Maintenance Regulation Of Dendritic Spine Maintenance Glycosaminoglycan Binding Extrinsic Component Of Membrane Negative Regulation Of Long-term Synaptic Potentiation Aspartic-type Endopeptidase Inhibitor Activity Intracellular Copper Ion Homeostasis Negative Regulation Of Calcium-mediated Signaling Positive Regulation Of Protein Targeting To Membrane Dendritic Spine Maintenance Type 8 Metabotropic Glutamate Receptor Binding Negative Regulation Of Amyloid-beta Formation Molecular Function Activator Activity Cuprous Ion Binding Cupric Ion Binding Regulation Of Glutamate Receptor Signaling Pathway Copper Ion Homeostasis Negative Regulation Of Interleukin-2 Production Cellular Response To Copper Ion Negative Regulation Of Protein Processing Negative Regulation Of Protein Maturation Negative Regulation Of Activated T Cell Proliferation Lamin Binding Type 5 Metabotropic Glutamate Receptor Binding Negative Regulation Of Amyloid Precursor Protein Catabolic Process Regulation Of Protein Targeting To Membrane Regulation Of Activated T Cell Proliferation Regulation Of Long-term Synaptic Potentiation Long-term Memory Neuron Projection Organization Regulation Of Amyloid-beta Formation Terminal Bouton Negative Regulation Of Type II Interferon Production Dendritic Spine Organization Postsynapse Organization Regulation Of Calcineurin-mediated Signaling Response To Copper Ion Regulation Of Calcineurin-NFAT Signaling Cascade Negative Regulation Of T Cell Receptor Signaling Pathway Response To Cadmium Ion Regulation Of Calcium Ion Import Copper Ion Binding Molecular Condensate Scaffold Activity