GBA2

Description		glucosylceramidase beta 2
Image		No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Smooth Endoplasmic Reticulum Golgi Apparatus Cytosol Plasma Membrane Membrane
	Molecular Function	Galactosylceramidase Activity Glucosylceramidase Activity Hydrolase Activity, Hydrolyzing O-glycosyl Compounds Beta-glucosidase Activity Transferase Activity Glycosyltransferase Activity Hydrolase Activity Hydrolase Activity, Acting On Glycosyl Bonds Glucosyltransferase Activity Steryl-beta-glucosidase Activity
	Biological Process	Carbohydrate Metabolic Process Lipid Metabolic Process Sphingolipid Metabolic Process Glucosylceramide Catabolic Process Central Nervous System Development Steroid Metabolic Process Cholesterol Metabolic Process Bile Acid Metabolic Process Glycoside Catabolic Process Central Nervous System Neuron Development Regulation Of Actin Filament Polymerization Regulation Of Microtubule Polymerization Small Molecule Metabolic Process Glycosphingolipid Catabolic Process Regulation Of Membrane Lipid Distribution
Pathways		Glycosphingolipid catabolism
Drugs
Diseases
GWAS		Brain morphology (MOSTest) ( 32665545)
Novel Interacting Genes		1 novel interacting genes: UBAP2
Interacting Genes		2 interacting genes: APP MTNR1A
Entrez ID		57704
HPRD ID		13569
Ensembl ID		ENSG00000070610
Uniprot IDs		Q9HCG7
PDB IDs
Enriched GO Terms of Interacting Partners?		Mating Behavior Reproductive Behavior Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Acetylcholine Receptor Activator Activity PTB Domain Binding Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Endothelin Production Growth Cone Filopodium Lipoprotein Particle Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Receptor Complex Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Cellular Response To Norepinephrine Stimulus Astrocyte Activation Involved In Immune Response Low-density Lipoprotein Particle Mediated Signaling Melatonin Receptor Activity Intermediate-density Lipoprotein Particle Axon Midline Choice Point Recognition Positive Regulation Of Amyloid Fibril Formation Growth Factor Receptor Binding Main Axon Regulation Of Spontaneous Synaptic Transmission NMDA Selective Glutamate Receptor Signaling Pathway Regulation Of Synapse Structure Or Activity Regulation Of Toll Signaling Pathway Axon Choice Point Recognition Heparan Sulfate Binding Signaling Receptor Activator Activity Peptidase Activator Activity Cellular Response To Manganese Ion Antifungal Humoral Response Nuclear Envelope Lumen Negative Regulation Of Blood Circulation Regulation Of Superoxide Anion Generation Collateral Sprouting Heparan Sulfate Proteoglycan Binding Acetylcholine Receptor Binding Golgi-associated Vesicle
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