GPAM

Description		glycerol-3-phosphate acyltransferase, mitochondrial
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GO Annotations	Cellular Component	Mitochondrion Mitochondrial Outer Membrane Plasma Membrane Membrane
	Molecular Function	Glycerol-3-phosphate O-acyltransferase Activity Protein Binding O-acyltransferase Activity Transferase Activity Acyltransferase Activity
	Biological Process	Regulation Of Cytokine Production Lipid Metabolic Process Fatty Acid Metabolic Process Acyl-CoA Metabolic Process Triglyceride Metabolic Process Glycerophospholipid Metabolic Process Diacylglycerol Biosynthetic Process Phosphatidic Acid Biosynthetic Process Phosphatidylglycerol Biosynthetic Process Activation-induced Cell Death Of T Cells Phospholipid Biosynthetic Process Response To Glucose CDP-diacylglycerol Biosynthetic Process Triglyceride Biosynthetic Process Positive Regulation Of Multicellular Organism Growth Positive Regulation Of Activated T Cell Proliferation Activated T Cell Proliferation Defense Response To Virus Fatty Acid Homeostasis Phospholipid Homeostasis Negative Regulation Of Activation-induced Cell Death Of T Cells
Pathways		Synthesis of PA Activation of gene expression by SREBF (SREBP) Triglyceride biosynthesis RUNX1 regulates estrogen receptor mediated transcription Estrogen-dependent gene expression MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis
Drugs
Diseases
GWAS		Alanine aminotransferase levels ( 33339817 33547301 34315874) Alanine transaminase levels ( 29403010) Apolipoprotein A1 levels ( 32203549) Aspartate aminotransferase levels ( 34315874 33547301) Cholesterol, total ( 20686565 25961943 24097068) HDL cholesterol ( 25961943 30275531) HDL cholesterol levels ( 32203549 30698716) HDL cholesterol levels in current drinkers ( 30698716) HDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) HDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Height ( 31562340) High density lipoprotein cholesterol levels ( 33339817 29403010) LDL cholesterol ( 20686565 24097068 25961943 30275531) LDL cholesterol levels ( 30698716 28334899 32203549) LDL cholesterol levels in current drinkers ( 30698716) LDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) LDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Lean body mass ( 28552196) Liver enzyme levels (alanine transaminase) ( 33972514) Liver enzyme levels (alkaline phosphatase) ( 33972514) Low density lipoprotein cholesterol levels ( 33339817 32154731) Metabolite levels ( 31628463) Percent liver fat ( 34128465) Plateletcrit ( 32888494) Serum alkaline phosphatase levels ( 29403010 33339817 33547301) Total cholesterol levels ( 30275531 33339817 28334899 29403010) Triglyceride levels ( 32203549) Triglyceride levels in current drinkers ( 30698716) Triglyceride levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) Triglyceride levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716)
Interacting Genes		3 interacting genes: APP CIDEB FBXO7
Entrez ID		57678
HPRD ID		03865
Ensembl ID		ENSG00000119927
Uniprot IDs		Q8N1G6 Q9HCL2
PDB IDs		8E4Y 8E50
Enriched GO Terms of Interacting Partners?		Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Glial Cytoplasmic Inclusion Classical Lewy Body Lewy Body Corona Lewy Neurite Acetylcholine Receptor Activator Activity PTB Domain Binding Regulation Of Neuron Apoptotic Process Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Intermediate-density Lipoprotein Particle Axon Midline Choice Point Recognition Regulation Of Intrinsic Apoptotic Signaling Pathway Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Amyloid Fibril Formation Positive Regulation Of Endothelin Production Growth Cone Filopodium Cellular Response To Norepinephrine Stimulus Regulation Of Apoptotic Process Lipoprotein Particle Growth Factor Receptor Binding Main Axon Regulation Of Programmed Cell Death Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Astrocyte Activation Involved In Immune Response Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Low-density Lipoprotein Particle Mediated Signaling Lewy Body Core Lipid Droplet Fusion Regulation Of Spontaneous Synaptic Transmission NMDA Selective Glutamate Receptor Signaling Pathway Regulation Of Synapse Structure Or Activity Regulation Of Toll Signaling Pathway Protein Heterodimerization Activity Axon Choice Point Recognition Heparan Sulfate Binding Signaling Receptor Activator Activity Peptidase Activator Activity Cellular Response To Manganese Ion Regulation Of Apoptotic Signaling Pathway Regulation Of Plasma Membrane Bounded Cell Projection Organization Negative Regulation Of Blood Circulation
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