KLHL1

Description		kelch like family member 1
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytoskeleton Dendrite Cul3-RING Ubiquitin Ligase Complex Neuronal Cell Body
	Molecular Function	Actin Binding Protein Binding Ubiquitin-like Ligase-substrate Adaptor Activity
	Biological Process	Locomotory Behavior Adult Walking Behavior Dendrite Development Cerebellar Purkinje Cell Layer Development Actin Cytoskeleton Organization Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Pathways
Drugs
Diseases
GWAS		Asthma (time to childhood onset) in early life tobacco smoke exposure ( 31379025) Asthma (time to childhood onset) x early life tobacco smoke interaction ( 31379025) Bilirubin levels ( 22085899) Chronotype ( 30696823) Cleft lip with or without cleft palate x maternal periconceptional vitamin use interaction (parent of origin effect) ( 31372216) Cognitive performance ( 19734545) Homeostasis model assessment of beta-cell function (dietary factor interaction) ( 24204828) Mortality in sepsis ( 27639821) Obesity-related traits ( 23251661) Photic sneeze reflex ( 27182965) Response to amphetamines ( 22952603) Sensory peripheral neuropathy in microtubule targeting agent-treated breast cancer ( 32562552) Spontaneous preterm birth without premature rupture of membranes ( 31194736) Tonsillectomy ( 27182965 28928442) Trigger finger ( 32740585) Verbal declarative memory ( 25648963)
Interacting Genes		2 interacting genes: BMPR1B TGFBR1
Entrez ID		57626
HPRD ID		05623
Ensembl ID		ENSG00000150361
Uniprot IDs		B7Z3I8 F5H1J3 Q8TBJ7 Q9NR64
PDB IDs
Enriched GO Terms of Interacting Partners?		Transforming Growth Factor Beta Receptor Activity, Type I Transmembrane Receptor Protein Serine/threonine Kinase Activity Regulation Of Chondrocyte Differentiation SMAD Binding Regulation Of Cartilage Development Positive Regulation Of Apoptotic Signaling Pathway Regulation Of Extrinsic Apoptotic Signaling Pathway Receptor Complex Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Cellular Response To Growth Factor Stimulus Regionalization Vascular Endothelial Cell Proliferation Epicardium Morphogenesis Response To Growth Factor Proepicardium Development Angiogenesis Involved In Coronary Vascular Morphogenesis Transforming Growth Factor Beta Ligand-receptor Complex Ovarian Cumulus Expansion Positive Regulation Of Epithelial To Mesenchymal Transition Involved In Endocardial Cushion Formation Positive Regulation Of Tight Junction Disassembly Pattern Specification Process Regulation Of Apoptotic Signaling Pathway Protein Serine/threonine Kinase Activity Negative Regulation Of Chondrocyte Proliferation HFE-transferrin Receptor Complex Protein Kinase Activity Animal Organ Morphogenesis BMP Receptor Activity Endochondral Bone Morphogenesis Positive Regulation Of Mesenchymal Stem Cell Proliferation Myofibroblast Differentiation Activin Receptor Complex Activin Receptor Activity, Type I Ventricular Compact Myocardium Morphogenesis Parathyroid Gland Development Germ Cell Migration Transforming Growth Factor Beta Receptor Activity Trophoblast Cell Migration Regulation Of Epithelial To Mesenchymal Transition Involved In Endocardial Cushion Formation Positive Regulation Of Programmed Cell Death Positive Regulation Of Apoptotic Process Coronary Artery Morphogenesis Positive Regulation Of Cardiac Epithelial To Mesenchymal Transition Type II Transforming Growth Factor Beta Receptor Binding Positive Regulation Of Extracellular Matrix Assembly Endothelial Cell Activation Kinase Activity Coronary Vasculature Morphogenesis Activin Binding
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