LRFN2

Description		leucine rich repeat and fibronectin type III domain containing 2
Image		No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Cell Surface Membrane Synapse Postsynaptic Membrane Schaffer Collateral - CA1 Synapse Presynapse Postsynapse Postsynaptic Density Membrane
	Molecular Function
	Biological Process	Modulation Of Chemical Synaptic Transmission Regulation Of Postsynapse Organization
Pathways		Synaptic adhesion-like molecules
Drugs
Diseases
GWAS		Adult body size ( 32376654) Adventurousness ( 30643258) Body mass index ( 28448500 28892062) Body mass index (joint analysis main effects and physical activity interaction) ( 28448500) Body mass index in physically active individuals ( 28448500) General risk tolerance (MTAG) ( 30643258) Hand grip strength ( 29691431) HDL cholesterol levels in HIV infection ( 33109212) Heel bone mineral density ( 30598549) Incident coronary heart disease ( 26950853) Multiple cancers (lung cancer, gastric cancer, and squamous cell carcinoma) ( 23103227) Obesity-related traits ( 23251661) Triglyceride change in response to fenofibrate in statin-treated type 2 diabetes ( 28736931) Type 2 diabetes ( 30297969) Waist circumference ( 25673412) Waist-hip ratio ( 28552196) Waist-to-hip ratio adjusted for BMI ( 28552196)
Interacting Genes		1 interacting genes: SNCA
Entrez ID		57497
HPRD ID		17444
Ensembl ID		ENSG00000156564
Uniprot IDs		Q9ULH4
PDB IDs
Enriched GO Terms of Interacting Partners?		Response To Desipramine Negative Regulation Of Norepinephrine Uptake Phospholipase D Inhibitor Activity Positive Regulation Of SNARE Complex Assembly Negative Regulation Of Dopamine Uptake Involved In Synaptic Transmission Regulation Of Norepinephrine Uptake Negative Regulation Of Mitochondrial Electron Transport, NADH To Ubiquinone Positive Regulation Of Hydrogen Peroxide Catabolic Process Negative Regulation Of Serotonin Uptake Transporter Regulator Activity Negative Regulation Of Chaperone-mediated Autophagy Negative Regulation Of Dopamine Metabolic Process Regulation Of Serotonin Uptake Negative Regulation Of Thrombin-activated Receptor Signaling Pathway Negative Regulation Of Catecholamine Metabolic Process Dopamine Uptake Involved In Synaptic Transmission Mitochondrial ATP Synthesis Coupled Electron Transport Cuprous Ion Binding Regulation Of Chaperone-mediated Autophagy Response To Iron(II) Ion Dopamine Biosynthetic Process Regulation Of Dopamine Uptake Involved In Synaptic Transmission Negative Regulation Of Cellular Respiration Negative Regulation Of Oxidative Phosphorylation Regulation Of Acyl-CoA Biosynthetic Process Supramolecular Fiber Catecholamine Uptake Dopamine Uptake Positive Regulation Of Inositol Phosphate Biosynthetic Process SNARE Complex Assembly Cellular Response To Epinephrine Stimulus Regulation Of SNARE Complex Assembly Negative Regulation Of Microtubule Polymerization Negative Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway ATP Synthesis Coupled Electron Transport Positive Regulation Of Receptor Recycling Synaptic Transmission, Dopaminergic Response To Epinephrine Positive Regulation Of Neurotransmitter Secretion Regulation Of Hydrogen Peroxide Metabolic Process Platelet Alpha Granule Membrane Dynein Complex Binding Synaptic Vesicle Priming Dopamine Transport Inclusion Body Neurotransmitter Reuptake Catecholamine Biosynthetic Process Response To Magnesium Ion Behavioral Response To Cocaine Phospholipase Binding
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