PPM1H

Description		protein phosphatase, Mg2+/Mn2+ dependent 1H
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Mitochondrion Synapse Glutamatergic Synapse
	Molecular Function	Phosphoprotein Phosphatase Activity Protein Serine/threonine Phosphatase Activity [pyruvate Dehydrogenase (acetyl-transferring)]-phosphatase Activity Protein Binding Hydrolase Activity Identical Protein Binding
	Biological Process
Pathways
Drugs
Diseases
GWAS		Chronotype ( 30696823) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) Heel bone mineral density ( 30598549) High density lipoprotein cholesterol levels ( 34074324) Mean corpuscular volume ( 32888494) Morning person ( 30696823) Obesity-related traits ( 23251661) Obsessive-compulsive traits ( 33531474) Red cell distribution width ( 32888494) Response to antioxidants and zinc in age-related macular degeneration (disease progression) ( 33751636) Sense of smell ( 26632684) Waist circumference ( 20966902)
Interacting Genes		1 interacting genes: AKT1
Entrez ID		57460
HPRD ID		15166
Ensembl ID		ENSG00000111110
Uniprot IDs		Q9ULR3
PDB IDs		7KPR 7L4I 7L4J 7N0Z
Enriched GO Terms of Interacting Partners?		Response To Rapamycin Positive Regulation Of Protein Localization To Endoplasmic Reticulum Nitric-oxide Synthase Regulator Activity Regulation Of Anaphase-promoting Complex-dependent Catabolic Process Negative Regulation Of SREBP Signaling Pathway Response To Insulin-like Growth Factor Stimulus Negative Regulation Of Fatty Acid Beta-oxidation Positive Regulation Of TORC2 Signaling TRNA Stabilization Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To Hydrogen Peroxide Potassium Channel Activator Activity Mammalian Oogenesis Stage RNA (guanine-N7)-methylation Negative Regulation Of Fatty Acid Transport Regulation Of Type B Pancreatic Cell Development Negative Regulation Of Long-chain Fatty Acid Import Across Plasma Membrane Cellular Response To Peptide Beta-arrestin-dependent Dopamine Receptor Signaling Pathway Maintenance Of Protein Location In Mitochondrion TRNA (guanine-N7)-methylation Activation-induced Cell Death Of T Cells Regulation Of Long-chain Fatty Acid Import Into Cell TORC2 Complex Binding Cellular Response To Rapamycin Peripheral Nervous System Myelin Maintenance Regulation Of Endodeoxyribonuclease Activity Negative Regulation Of Hydrogen Peroxide-induced Neuron Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Deoxyribonuclease Activity Negative Regulation Of Protein Localization To Lysosome Positive Regulation Of Anaphase-promoting Complex-dependent Catabolic Process Regulation Of TRNA Methylation Positive Regulation Of Toll-like Receptor Signaling Pathway Positive Regulation Of Endodeoxyribonuclease Activity SREBP-SCAP Complex Retention In Endoplasmic Reticulum Vascular Endothelial Cell Response To Laminar Fluid Shear Stress Maternal Placenta Development Regulation Of SREBP Signaling Pathway Maintenance Of Protein Localization In Endoplasmic Reticulum Anoikis PERK-mediated Unfolded Protein Response Negative Regulation Of PERK-mediated Unfolded Protein Response Cellular Response To Granulocyte Macrophage Colony-stimulating Factor Stimulus Protein K29-linked Ubiquitination Cellular Response To Ether Calcium Import Into The Mitochondrion Cellular Response To Oxidised Low-density Lipoprotein Particle Stimulus Negative Regulation Of Hydrogen Peroxide-mediated Programmed Cell Death Response To UV-A Regulation Of TORC2 Signaling Mammary Gland Epithelial Cell Differentiation
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