SALL4

Description		spalt like transcription factor 4
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GO Annotations	Cellular Component	Heterochromatin Nucleus Nucleoplasm Cytoplasm Protein-containing Complex
	Molecular Function	DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding Protein Binding Zinc Ion Binding Metal Ion Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II In Utero Embryonic Development Inner Cell Mass Cell Proliferation Neural Tube Closure Ventricular Septum Development Regulation Of Transcription By RNA Polymerase II Heart Development Tissue Development Neural Tube Development Embryonic Limb Morphogenesis Somatic Stem Cell Population Maintenance Positive Regulation Of Transcription By RNA Polymerase II
Pathways		POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation Transcriptional regulation of pluripotent stem cells Regulation of PTEN gene transcription Regulation of PTEN gene transcription
Drugs
Diseases		Duane-radial ray syndrome and IVIC syndrome; Okihiro syndrome
GWAS		Male infertility ( 19478329) Neuroblastoma (pediatric) ( 32599975) Tourette's syndrome or obsessive-compulsive disorder ( 25158072)
Interacting Genes		1 interacting genes: RBBP4
Entrez ID		57167
HPRD ID		08458
Ensembl ID		ENSG00000101115
Uniprot IDs		Q9UJQ4
PDB IDs		5XWR 6UML 7BQU 7BQV 7Y3I 7Y3K 7Y3M 8CUC 8U15 8U16 8U17
Enriched GO Terms of Interacting Partners?		CAF-1 Complex DNA Replication-dependent Chromatin Assembly NURF Complex ATPase Complex ESC/E(Z) Complex NuRD Complex Sin3-type Complex Negative Regulation Of Stem Cell Population Maintenance Regulation Of Cell Fate Specification ATP-dependent Activity, Acting On DNA Nucleosomal DNA Binding Histone Deacetylase Complex Positive Regulation Of Stem Cell Population Maintenance Regulation Of Cell Fate Commitment Regulation Of Stem Cell Population Maintenance Regulation Of Stem Cell Differentiation Nucleosome Assembly Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Histone Deacetylase Binding Nucleosome Organization Histone Binding Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway DNA Replication Chromosome, Telomeric Region
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