AKR1B10

Description		aldo-keto reductase family 1 member B10
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GO Annotations	Cellular Component	Extracellular Region Mitochondrion Lysosome Cytosol
	Molecular Function	Retinal Dehydrogenase (NAD+) Activity Aldose Reductase (NADPH) Activity Protein Binding Alcohol Dehydrogenase (NADP+) Activity Oxidoreductase Activity Oxidoreductase Activity, Acting On The CH-OH Group Of Donors, NAD Or NADP As Acceptor Geranylgeranyl Reductase Activity Allyl-alcohol Dehydrogenase Activity Indanol Dehydrogenase Activity All-trans-retinol Dehydrogenase (NADP+) Activity
	Biological Process	Retinoid Metabolic Process Lipid Metabolic Process Farnesol Catabolic Process Retinol Metabolic Process Daunorubicin Metabolic Process Doxorubicin Metabolic Process Cellular Detoxification Of Aldehyde
Pathways		Retinoid metabolism and transport
Drugs		Sulindac Fidarestat Tolrestat Nicotinamide adenine dinucleotide phosphate Exisulind Zopolrestat
Diseases
GWAS		Diastolic blood pressure ( 30224653) Familial lung adenocarcinoma ( 29924316) Medication use (agents acting on the renin-angiotensin system) ( 31015401) White matter growth ( 29682794)
Interacting Genes		1 interacting genes: TERF2IP
Entrez ID		57016
HPRD ID		05271
Ensembl ID		ENSG00000198074
Uniprot IDs		O60218
PDB IDs		1ZUA 4GA8 4GAB 4GQ0 4GQG 4I5X 4ICC 4JIH 4JII 4WEV 4XZL 4XZM 4XZN 5LIK 5LIU 5LIW 5LIX 5LIY 5M2F 5Y7N
Enriched GO Terms of Interacting Partners?		Negative Regulation Of DNA Recombination At Telomere Protein Localization To Chromosome, Telomeric Region Nuclear Telomere Cap Complex Protection From Non-homologous End Joining At Telomere Shelterin Complex Telomere Capping G-rich Strand Telomeric DNA Binding Telomere Maintenance In Response To DNA Damage Telomere Maintenance Via Telomere Lengthening Telomeric DNA Binding Nuclear Chromosome RNA-templated DNA Biosynthetic Process Telomere Maintenance Via Telomerase Negative Regulation Of Telomere Maintenance Phosphatase Binding Negative Regulation Of DNA Recombination Male Germ Cell Nucleus Positive Regulation Of Non-canonical NF-kappaB Signal Transduction Positive Regulation Of Telomere Maintenance Positive Regulation Of NF-kappaB Transcription Factor Activity Negative Regulation Of Chromosome Organization Regulation Of Double-strand Break Repair Via Homologous Recombination Negative Regulation Of Protein Phosphorylation DNA Biosynthetic Process Telomere Maintenance Protein Localization To Chromosome Regulation Of Non-canonical NF-kappaB Signal Transduction Positive Regulation Of Chromosome Organization Positive Regulation Of DNA-binding Transcription Factor Activity Regulation Of Telomere Maintenance Negative Regulation Of Phosphorylation Telomere Organization Negative Regulation Of DNA Metabolic Process Regulation Of DNA Recombination Regulation Of Double-strand Break Repair Negative Regulation Of Phosphate Metabolic Process Chromosome, Telomeric Region Regulation Of DNA-binding Transcription Factor Activity Positive Regulation Of Canonical NF-kappaB Signal Transduction Regulation Of DNA Repair Regulation Of Chromosome Organization Positive Regulation Of DNA Metabolic Process
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