ADAMTS9

Description		ADAM metallopeptidase with thrombospondin type 1 motif 9
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Endoplasmic Reticulum Cell Surface Extracellular Matrix
	Molecular Function	Endopeptidase Activity Metalloendopeptidase Activity Peptidase Activity Metallopeptidase Activity Zinc Ion Binding Hydrolase Activity Metal Ion Binding
	Biological Process	Lens Development In Camera-type Eye Heart Valve Morphogenesis Ventricular Cardiac Muscle Tissue Development Proteolysis Response To Bacterium Negative Regulation Of Endothelial Cell Migration Protein Transport Vesicle-mediated Transport Extracellular Matrix Organization Melanocyte Differentiation Aorta Morphogenesis Positive Regulation Of Melanocyte Differentiation Regulation Of Developmental Pigmentation Camera-type Eye Morphogenesis Cornea Development In Camera-type Eye Endothelial Cell-matrix Adhesion Negative Regulation Of Sprouting Angiogenesis
Pathways		Degradation of the extracellular matrix Defective B3GALTL causes PpS O-glycosylation of TSR domain-containing proteins
Drugs
Diseases		Type II diabetes mellitus
GWAS		A body shape index ( 34021172) Age-related macular degeneration ( 23455636) Alzheimer's disease (age of onset) ( 22005931) Asthma ( 26620591) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Diastolic blood pressure ( 27618452) Diisocyanate-induced asthma ( 25918132) Early-onset Parkinson's disease ( 28256260) Hip circumference ( 25673412) Liver enzyme levels (alanine transaminase) ( 24124411) Liver enzyme levels (aspartate transaminase) ( 24124411) Refractive error ( 32231278) Sexual dimorphism in anthropometric traits ( 23754948) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Systolic blood pressure ( 27841878) Type 2 diabetes ( 18372903 31049640 30297969 29358691 22885922) Visceral adipose tissue adjusted for BMI ( 22589738) Visceral adipose tissue/subcutaneous adipose tissue ratio ( 22589738) Waist circumference adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction) ( 28448500) Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction) ( 28443625) Waist circumference adjusted for BMI in active individuals ( 28448500) Waist circumference adjusted for BMI in non-smokers ( 28443625) Waist circumference adjusted for body mass index ( 34021172 25673412 28448500) Waist-hip index ( 34021172) Waist-hip ratio ( 20935629 25673412) Waist-to-hip ratio adjusted for BMI ( 34021172 26426971) Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist-to-hip ratio adjusted for BMI (age <50) ( 26426971) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction) ( 28448500) Waist-to-hip ratio adjusted for BMI (joint analysis main effects and smoking interaction) ( 28443625) Waist-to-hip ratio adjusted for BMI in active individuals ( 28448500) Waist-to-hip ratio adjusted for BMI in inactive individuals ( 28448500) Waist-to-hip ratio adjusted for BMI in non-smokers ( 28443625) Waist-to-hip ratio adjusted for BMI in smokers ( 28443625) Waist-to-hip ratio adjusted for BMI x sex interaction ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971) Waist-to-hip ratio adjusted for body mass index ( 25673412 28448500) White matter integrity (bipolar disorder risk interaction) ( 23218918)
Interacting Genes		2 interacting genes: DYRK1A LIMS1
Entrez ID		56999
HPRD ID		05662
Ensembl ID		ENSG00000163638
Uniprot IDs		Q9P2N4
PDB IDs
Enriched GO Terms of Interacting Partners?		Histone H3T45 Kinase Activity Actin Binding Negative Regulation Of Heterochromatin Formation Regulation Of Neurofibrillary Tangle Assembly Splicing Factor Binding RNA Polymerase II CTD Heptapeptide Repeat Kinase Activity Neurofilament Regulation Of Heterochromatin Formation Negative Regulation Of Microtubule Polymerization Negative Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Positive Regulation Of Integrin-mediated Signaling Pathway Tau-protein Kinase Activity Negative Regulation Of MRNA Splicing, Via Spliceosome Regulation Of Chromatin Organization Regulation Of Inclusion Body Assembly Regulation Of Integrin-mediated Signaling Pathway Protein Serine/threonine/tyrosine Kinase Activity Negative Regulation Of RNA Splicing Positive Regulation Of RNA Splicing Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Positive Regulation Of Gene Expression Regulation Of Amyloid-beta Formation Negative Regulation Of Microtubule Polymerization Or Depolymerization Non-membrane Spanning Protein Tyrosine Kinase Activity Negative Regulation Of Signal Transduction By P53 Class Mediator Tau Protein Binding Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Positive Regulation Of Focal Adhesion Assembly Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of RNA Metabolic Process Regulation Of Microtubule Polymerization Tubulin Binding Regulation Of Amyloid Precursor Protein Catabolic Process Cytoskeletal Protein Binding Double-strand Break Repair Via Nonhomologous End Joining Peptidyl-tyrosine Phosphorylation Regulation Of Alternative MRNA Splicing, Via Spliceosome Regulation Of Substrate Adhesion-dependent Cell Spreading Positive Regulation Of Cell-matrix Adhesion Tumor Necrosis Factor-mediated Signaling Pathway Regulation Of Focal Adhesion Assembly Cellular Response To Transforming Growth Factor Beta Stimulus Response To Transforming Growth Factor Beta Regulation Of Cell-substrate Junction Organization Regulation Of Amide Metabolic Process Epithelial To Mesenchymal Transition Actin Filament Positive Regulation Of GTPase Activity Regulation Of Microtubule Polymerization Or Depolymerization Negative Regulation Of MRNA Metabolic Process
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