CDC42SE2

Description		CDC42 small effector 2
Image		No pdb structure
GO Annotations	Cellular Component	Phagocytic Cup Cytoplasm Cytoskeleton Plasma Membrane Membrane Cell Projection
	Molecular Function	Protein Binding Small GTPase Binding Signaling Adaptor Activity
	Biological Process	Phagocytosis Regulation Of Cell Shape Regulation Of Signal Transduction Regulation Of Rho Protein Signal Transduction
Pathways		CDC42 GTPase cycle
Drugs
Diseases
GWAS		Alzheimer's disease in APOE e4- carriers ( 25778476) Apolipoprotein A1 levels ( 32203549) Brain morphology (MOSTest) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Crohn's disease ( 28067908) Diisocyanate-induced asthma ( 25918132) Fasting glucose ( 34074324) HDL cholesterol levels ( 32203549) Inflammatory bowel disease ( 28067908) Itch intensity from mosquito bite ( 28199695) Itch intensity from mosquito bite adjusted by bite size ( 28199695) Lymphocyte count ( 32888494) Mosquito bite size ( 28199695) Perceived unattractiveness to mosquitoes ( 28199695) Subcortical volume (MOSTest) ( 32665545) Triglyceride levels ( 32203549) Ulcerative colitis ( 28067908)
Novel Interacting Genes		1 novel interacting genes: NEU1
Interacting Genes		2 interacting genes: RAC1 UBC
Entrez ID		56990
HPRD ID		16695
Ensembl ID		ENSG00000158985
Uniprot IDs		Q9NRR3
PDB IDs
Enriched GO Terms of Interacting Partners?		Alpha-sialidase Activity Positive Regulation Of Ovarian Follicle Development Negative Regulation Of Interleukin-23 Production Regulation Of ERK5 Cascade Angiotensin-activated Signaling Pathway Involved In Heart Process Embryonic Olfactory Bulb Interneuron Precursor Migration Cerebral Cortex GABAergic Interneuron Development Rho GDP-dissociation Inhibitor Binding Regulation Of Cell Adhesion Involved In Heart Morphogenesis Extracellular Exosome Ganglioside Catabolic Process Exo-alpha-sialidase Activity Kinocilium Positive Regulation Of Bicellular Tight Junction Assembly Regulation Of Interleukin-23 Production Regulation Of Ovarian Follicle Development G Protein-coupled Receptor Signaling Pathway Involved In Heart Process Auditory Receptor Cell Morphogenesis Regulation Of Neuron Maturation Positive Regulation Of Skeletal Muscle Acetylcholine-gated Channel Clustering Thioesterase Binding Erythrocyte Enucleation Hepatocyte Growth Factor Receptor Signaling Pathway Engulfment Of Apoptotic Cell Regulation Of Skeletal Muscle Acetylcholine-gated Channel Clustering Tangential Migration From The Subventricular Zone To The Olfactory Bulb Positive Regulation Of Receptor Clustering Negative Regulation Of Fibroblast Migration Oligosaccharide Catabolic Process Midbrain Dopaminergic Neuron Differentiation Regulation Of Hydrogen Peroxide Metabolic Process NADPH Oxidase Complex Sphingosine-1-phosphate Receptor Signaling Pathway Sphingolipid Mediated Signaling Pathway Positive Regulation Of Ruffle Assembly Interneuron Migration Ruffle Assembly Protein Tag Activity Glycosphingolipid Catabolic Process Regulation Of Receptor Clustering Glycolipid Catabolic Process Ceramide Catabolic Process Ganglioside Metabolic Process Angiotensin-activated Signaling Pathway Respiratory Burst Regulation Of Cell Maturation Regulation Of Bicellular Tight Junction Assembly Superoxide Anion Generation GTP-dependent Protein Binding Cerebral Cortex Radially Oriented Cell Migration
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