SPIRE1

Name	spire type actin nucleation factor 1
Structure
Novel Interactors	3 novel interactors: CEP192 ETS1 PLEKHA5
Interactors	1 interactors: BBS4
GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Mitochondrial Outer Membrane Cytosol Cytoskeleton Plasma Membrane Cell Cortex Membrane Cytoplasmic Vesicle Membrane Cytoplasmic Vesicle Cleavage Furrow Perinuclear Region Of Cytoplasm
	Molecular Function	Actin Binding Protein Binding Microtubule Binding
	Biological Process	Immune System Process Protein Transport Vesicle-mediated Transport Actin Cytoskeleton Organization Cleavage Furrow Formation Polar Body Extrusion After Meiotic Divisions Actin Nucleation Innate Immune Response Intracellular Transport Golgi Vesicle Transport Establishment Of Meiotic Spindle Localization Actin Filament Network Formation Formin-nucleated Actin Cable Assembly Positive Regulation Of Mitochondrial Fission Positive Regulation Of Double-strand Break Repair
GWAS	Carotid plaque burden ( 28282560 ) Hematocrit ( 32888494 ) Hemoglobin ( 32888494 ) Immune response to smallpox vaccine (IL-6) ( 22542470 ) Red blood cell count ( 32888494 )
Entrez ID	56907
HPRD ID	11600
Ensembl ID	ENSG00000134278
Uniprot IDs	J3KNG6 Q08AE8
PDB IDs	2YLE 2YLF 3R7G 3RBW
GO Terms Enriched among Interactors ?	Pericentriolar Material Protein Localization To Centrosome Protein Localization To Cytoskeleton Centrosome Cycle Microtubule Organizing Center Organization Centrosome-templated Microtubule Nucleation Centriole RNA Polymerase II-specific DNA-binding Transcription Factor Binding Procentriole Sensory Processing Negative Regulation Of Appetite By Leptin-mediated Signaling Pathway Microtubule Nucleation By Microtubule Organizing Center Protein Localization To Photoreceptor Outer Segment Procentriole Replication Complex BBSome PML Body Organization Microtubule Anchoring At Centrosome Protein Localization To Non-motile Cilium Retinal Rod Cell Development Negative Regulation Of Appetite Fat Pad Development Erythrocyte Homeostasis Leptin-mediated Signaling Pathway Regulation Of Non-motile Cilium Assembly Regulation Of Cilium Beat Frequency Involved In Ciliary Motility Establishment Of Melanosome Localization Regulation Of Response To Food Sperm Flagellum Assembly Regulation Of Cilium Beat Frequency Photoreceptor Cell Outer Segment Organization Melanosome Localization Microtubule Cytoskeleton Organization Response To Leptin Brain Morphogenesis Microtubule Anchoring Striatum Development Melanosome Transport Ventricular System Development Face Development Pigment Granule Transport Dynactin Binding Retina Homeostasis Microtubule Anchoring At Microtubule Organizing Center Regulation Of Appetite Negative Regulation Of Systemic Arterial Blood Pressure Positive Regulation Of Leukocyte Adhesion To Vascular Endothelial Cell Nuclear Body Organization Reproductive System Development Phosphatidylinositol-5-phosphate Binding Centriole Replication