SPHK2

Gene Name		sphingosine kinase 2
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Lysosomal Membrane Cytosol Membrane
	Molecular Function	NAD+ Kinase Activity Diacylglycerol Kinase Activity Protein Binding ATP Binding Sphinganine Kinase Activity Ras GTPase Binding D-erythro-sphingosine Kinase Activity
	Biological Process	Blood Vessel Development Sphingolipid Metabolic Process Sphinganine-1-phosphate Biosynthetic Process Sphingosine Metabolic Process Protein Kinase C-activating G-protein Coupled Receptor Signaling Pathway Brain Development Cell Proliferation Positive Regulation Of Cell Proliferation Sphingolipid Biosynthetic Process Negative Regulation Of Apoptotic Process Small Molecule Metabolic Process Lipid Phosphorylation
Pathways		Sphingolipid metabolism Metabolism of lipids and lipoproteins Sphingolipid de novo biosynthesis
Drugs
Diseases
GWAS		Bipolar disorder ( 21926972) Crohn's disease ( 23128233)
Protein-protein Interactions		2 interactors: FYN LYN
Entrez ID		56848
HPRD ID		06157
Ensembl ID		ENSG00000063176
Uniprot IDs		B3KV83 M0R344 Q9NRA0
PDB IDs
Enriched GO Terms of Interacting Partners?		Peptidyl-tyrosine Autophosphorylation T Cell Costimulation Ephrin Receptor Signaling Pathway Antigen Receptor-mediated Signaling Pathway Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Fc-gamma Receptor Signaling Pathway Fc Receptor Mediated Stimulatory Signaling Pathway Platelet Activation Protein Autophosphorylation Positive Regulation Of T Cell Activation Positive Regulation Of Oligodendrocyte Progenitor Proliferation Negative Regulation Of Mast Cell Proliferation Positive Regulation Of Neuron Projection Development Positive Regulation Of Homotypic Cell-cell Adhesion Leukocyte Migration Fc-epsilon Receptor Signaling Pathway Positive Regulation Of Cell-cell Adhesion Phagocytosis Fc Receptor Signaling Pathway Positive Regulation Of Cell Projection Organization Peptidyl-tyrosine Phosphorylation Immune Response-activating Cell Surface Receptor Signaling Pathway Regulation Of T Cell Activation Positive Regulation Of Fc Receptor Mediated Stimulatory Signaling Pathway Positive Regulation Of Cell Activation Cellular Response To Peptide Hormone Stimulus Cellular Response To Peptide Positive Regulation Of Neuron Differentiation Tolerance Induction To Self Antigen Fc Receptor Mediated Inhibitory Signaling Pathway Positive Regulation Of Dendritic Cell Apoptotic Process Regulation Of Cell-cell Adhesion Immune Response-regulating Cell Surface Receptor Signaling Pathway Positive Regulation Of Cell Adhesion Regulation Of Neuron Projection Development Axon Guidance Regulation Of Lymphocyte Activation Positive Regulation Of Neurogenesis Blood Coagulation Hemostasis Response To Peptide Hormone Negative Regulation Of Toll-like Receptor 2 Signaling Pathway Immune Response-inhibiting Cell Surface Receptor Signaling Pathway Cellular Response To Organonitrogen Compound Immune Response-regulating Signaling Pathway Regulation Of Cell Activation Regulation Of Cell Projection Organization Response To Peptide Leukocyte Activation Positive Regulation Of Cell Development
Tagcloud ?		accumulate actions activate affecting analyze annexin antagonistic antagonized apoptotic assay atra blotting cip1 clonogenic colon cytometry express fitc g1 ht interference phosphate pi produce rarbeta s1p sphingosine trans waf1