SPHK2

Description		sphingosine kinase 2
Image		No pdb structure
GO Annotations	Cellular Component	Nucleosome Nucleus Nucleoplasm Cytoplasm Mitochondrion Mitochondrial Inner Membrane Lysosome Lysosomal Membrane Endoplasmic Reticulum Cytosol Membrane Intracellular Membrane-bounded Organelle
	Molecular Function	Nucleotide Binding Lipid Kinase Activity Protein Binding ATP Binding Sphingosine Kinase Activity Kinase Activity Transferase Activity Small GTPase Binding Sphingosine-1-phosphate Receptor Activity Histone Binding
	Biological Process	Blood Vessel Development Positive Regulation Of Cytokine Production Involved In Immune Response Sphingosine-1-phosphate Receptor Signaling Pathway Lipid Metabolic Process Sphinganine-1-phosphate Biosynthetic Process Sphingosine Metabolic Process Brain Development Female Pregnancy Cell Population Proliferation Positive Regulation Of Cell Population Proliferation Sphingolipid Biosynthetic Process Negative Regulation Of Cell Growth Positive Regulation Of Interleukin-13 Production Positive Regulation Of Interleukin-6 Production Positive Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Mast Cell Activation Involved In Immune Response Regulation Of Amide Metabolic Process Intracellular Signal Transduction Regulation Of Apoptotic Process Positive Regulation Of Apoptotic Process Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of Mast Cell Degranulation Transcription Initiation-coupled Chromatin Remodeling Sphingosine Biosynthetic Process Regulation Of Lipid Biosynthetic Process Regulation Of Transport Regulation Of Reactive Oxygen Species Biosynthetic Process Cellular Response To Phorbol 13-acetate 12-myristate Regulation Of Cytochrome-c Oxidase Activity Positive Regulation Of Ceramide Biosynthetic Process Regulation Of ATP Biosynthetic Process
Pathways		Sphingolipid de novo biosynthesis
Drugs		Opaganib
Diseases
GWAS		Bipolar disorder ( 21926972) Crohn's disease ( 23128233) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Immature fraction of reticulocytes ( 32888494) Lymphocyte count ( 32888494) Lymphocyte percentage of white cells ( 32888494) Mean reticulocyte volume ( 32888494) Myeloid white cell count ( 27863252) Neutrophil count ( 32888494) Neutrophil percentage of white cells ( 32888494) Non-oily fish consumption ( 32066663) Oily fish consumption ( 32066663) Pork consumption ( 32066663) Psoriasis ( 31376382) Red cell distribution width ( 32888494) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494) White blood cell count ( 32888494)
Interacting Genes		3 interacting genes: BCL2 FYN LYN
Entrez ID		56848
HPRD ID		06157
Ensembl ID		ENSG00000063176
Uniprot IDs		B3KV83 E9PCV4 Q9NRA0
PDB IDs
Enriched GO Terms of Interacting Partners?		Regulation Of Calcium Ion Transmembrane Transport Antigen Receptor-mediated Signaling Pathway Leukocyte Proliferation Mononuclear Cell Proliferation Lymphocyte Proliferation Response To Xenobiotic Stimulus Immune Response-activating Cell Surface Receptor Signaling Pathway Regulation Of Monoatomic Ion Transmembrane Transport Regulation Of Calcium Ion Transport Regulation Of B Cell Apoptotic Process Immune Response-regulating Cell Surface Receptor Signaling Pathway Regulation Of Monoatomic Cation Transmembrane Transport Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Stimulatory C-type Lectin Receptor Signaling Pathway Cellular Response To Lectin Fc Receptor Mediated Stimulatory Signaling Pathway B Cell Homeostasis Regulation Of Metal Ion Transport Positive Regulation Of Lymphocyte Activation Ephrin Receptor Binding Immune Response-activating Signaling Pathway Negative Regulation Of Inflammatory Response To Antigenic Stimulus Positive Regulation Of Cell Activation Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Fc-gamma Receptor Signaling Pathway Regulation Of Monoatomic Ion Transport Immune Response-regulating Signaling Pathway Activation Of Immune Response B Cell Proliferation Neuron Projection Development Lymphocyte Activation Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand T Cell Costimulation Non-membrane Spanning Protein Tyrosine Kinase Activity Regulation Of Cellular Localization Regulation Of Lymphocyte Activation B Cell Receptor Signaling Pathway Response To Axon Injury Ephrin Receptor Signaling Pathway Peptidyl-tyrosine Phosphorylation Fc Receptor Signaling Pathway Regulation Of Lymphocyte Apoptotic Process Leukocyte Activation Lymphocyte Homeostasis Regulation Of B Cell Proliferation Response To Hormone Innate Immune Response Activating Cell Surface Receptor Signaling Pathway Scaffold Protein Binding Regulation Of Cell Activation Cell Activation
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