FMN2

Description		formin 2
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GO Annotations	Cellular Component	Nucleus Nucleolus Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Spindle Cytosol Cytoskeleton Plasma Membrane Microvillus Cell Cortex Actin Cytoskeleton Membrane Cytoplasmic Vesicle Membrane Cytoplasmic Vesicle Perinuclear Region Of Cytoplasm Cell Periphery
	Molecular Function	Molecular_function Actin Binding
	Biological Process	DNA Damage Response Protein Transport Vesicle-mediated Transport Meiotic Chromosome Movement Towards Spindle Pole Cell Migration Actin Cytoskeleton Organization Intracellular Signal Transduction Polar Body Extrusion After Meiotic Divisions Negative Regulation Of Protein Catabolic Process Negative Regulation Of Apoptotic Process Intracellular Transport Oogenesis Actin Filament Bundle Assembly Establishment Of Meiotic Spindle Localization Homologous Chromosome Movement Towards Spindle Pole In Meiosis I Anaphase Formin-nucleated Actin Cable Assembly Cellular Response To Hypoxia Positive Regulation Of Double-strand Break Repair
Pathways
Drugs
Diseases
GWAS		Alzheimer's disease (cognitive decline) ( 23535033) Anger ( 24489884) Blond vs. brown/black hair color ( 30531825) Bone mineral density ( 23437003) Bone mineral density (Ward's triangle area) ( 27397699) Bullous pemphigoid ( 34011352) Carotid plaques in rheumatoid arthritis ( 30251476) Heel bone mineral density ( 28869591 30598549) Lumbar spine bone mineral density (integral) ( 27476799) Lumbar spine bone mineral density (trabecular) ( 27476799) Medication use (drugs affecting bone structure and mineralization) ( 31015401) Platelet count ( 32888494) Plateletcrit ( 32888494) Rapid automised naming of letters ( 30741946) Serum alkaline phosphatase levels ( 33547301) Total cholesterol levels ( 30498476) Urate levels in obese individuals ( 25811787)
Interacting Genes		4 interacting genes: CDC42 CFAP298 RAC1 RHOA
Entrez ID		56776
HPRD ID		10449
Ensembl ID		ENSG00000155816
Uniprot IDs		Q9HBL1 Q9NZ56
PDB IDs		2YLE 3R7G
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Stress Fiber Assembly Wnt Signaling Pathway, Planar Cell Polarity Pathway Membrane Invagination Non-canonical Wnt Signaling Pathway Positive Regulation Of Actin Filament Bundle Assembly G Protein Activity Regulation Of Stress Fiber Assembly G Protein-coupled Receptor Signaling Pathway Involved In Heart Process Thioesterase Binding Establishment Or Maintenance Of Cell Polarity Positive Regulation Of Supramolecular Fiber Organization Cell-cell Junction Organization Positive Regulation Of Cytoskeleton Organization Establishment Of Epithelial Cell Apical/basal Polarity Regulation Of Cell-substrate Adhesion GTP-dependent Protein Binding Establishment Of Apical/basal Cell Polarity Postsynapse Establishment Of Monopolar Cell Polarity Establishment Or Maintenance Of Monopolar Cell Polarity Polarized Epithelial Cell Differentiation Actin Filament Organization Regulation Of Actin Filament Organization Small GTPase-mediated Signal Transduction Regulation Of Microtubule-based Process Positive Regulation Of Lamellipodium Assembly Wnt Signaling Pathway Establishment Of Epithelial Cell Polarity Cerebral Cortex Cell Migration Phagocytosis, Engulfment Regulation Of Synapse Organization Positive Regulation Of Lamellipodium Organization GTPase Activity Cell Projection Regulation Of Lamellipodium Assembly Regulation Of Actin Cytoskeleton Organization Telencephalon Cell Migration Semaphorin-plexin Signaling Pathway Positive Regulation Of Cytokinesis GTP Binding Actin Cytoskeleton Organization Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Plasma Membrane Bounded Cell Projection Assembly Cell Projection Assembly Substantia Nigra Development Substrate Adhesion-dependent Cell Spreading Forebrain Cell Migration Regulation Of Actin Filament-based Process Regulation Of Supramolecular Fiber Organization Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity
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