KCNK13

Description		potassium two pore domain channel subfamily K member 13
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GO Annotations	Cellular Component	Plasma Membrane Membrane Monoatomic Ion Channel Complex
	Molecular Function	Potassium Channel Activity Protein Binding Outward Rectifier Potassium Channel Activity Potassium Ion Leak Channel Activity Identical Protein Binding Metal Ion Binding Protein Heterodimerization Activity
	Biological Process	Monoatomic Ion Transport Potassium Ion Transport Monoatomic Ion Transmembrane Transport Regulation Of Resting Membrane Potential Potassium Ion Transmembrane Transport Regulation Of NLRP3 Inflammasome Complex Assembly Regulation Of Excitatory Synapse Pruning
Pathways		Tandem pore domain halothane-inhibited K+ channel (THIK) Phase 4 - resting membrane potential
Drugs
Diseases
GWAS		Coronary artery calcification ( 23870195) Mortality in heart failure ( 20400778) Peak insulin response (BMI and insulin secretion adjusted) ( 28490609) Seasonality and depression ( 30217971)
Interacting Genes		1 interacting genes: LMNA
Entrez ID		56659
HPRD ID		09563
Ensembl ID		ENSG00000152315
Uniprot IDs		Q9HB14
PDB IDs		9BSN 9BWS 9BYI 9C07 9C09 9FT7
Enriched GO Terms of Interacting Partners?		Establishment Or Maintenance Of Microtubule Cytoskeleton Polarity Lamin Filament DNA Double-strand Break Attachment To Nuclear Envelope Ventricular Cardiac Muscle Cell Development Nuclear Pore Localization Negative Regulation Of Cardiac Muscle Hypertrophy In Response To Stress Negative Regulation Of Mesenchymal Cell Proliferation Structural Constituent Of Nuclear Lamina Nuclear Lamina Protein Localization To Nuclear Envelope Negative Regulation Of Release Of Cytochrome C From Mitochondria Regulation Of Cardiac Muscle Hypertrophy In Response To Stress Nuclear Envelope Organization Nuclear Migration Nucleus Localization Nuclear Lumen Negative Regulation Of Muscle Hypertrophy Cardiac Muscle Cell Development Regulation Of Mesenchymal Cell Proliferation Negative Regulation Of Cardiac Muscle Hypertrophy Regulation Of Release Of Cytochrome C From Mitochondria Cardiac Cell Development Cellular Senescence Striated Muscle Cell Development Protein-containing Complex Localization Regulation Of Cardiac Muscle Hypertrophy Chromosome Localization Muscle Cell Development Structural Constituent Of Cytoskeleton Site Of Double-strand Break Nucleus Organization Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Regulation Of Telomere Maintenance Regulation Of Mitochondrion Organization Protein Import Into Nucleus Import Into Nucleus Muscle Organ Development Nuclear Matrix Cellular Response To Decreased Oxygen Levels Cellular Response To Hypoxia Muscle Structure Development Heterochromatin Formation Cellular Response To Oxygen Levels Intermediate Filament Regulation Of Protein Localization To Nucleus Establishment Or Maintenance Of Cell Polarity Regulation Of Extrinsic Apoptotic Signaling Pathway Negative Regulation Of Gene Expression, Epigenetic Structural Molecule Activity Protein Localization To Nucleus
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