ANKH

Description		ANKH inorganic pyrophosphate transport regulator
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Plasma Membrane Membrane Outer Membrane
	Molecular Function	Phosphate Transmembrane Transporter Activity ATP Transmembrane Transporter Activity Inorganic Diphosphate Transmembrane Transporter Activity
	Biological Process	Skeletal System Development Locomotory Behavior Gene Expression Bone Mineralization Regulation Of Bone Mineralization Inorganic Diphosphate Transport Phosphate Ion Transmembrane Transport Muscle Cell Cellular Homeostasis Phosphate Ion Homeostasis Calcium Ion Homeostasis Transmembrane Transport Diphosphate Metabolic Process Cementum Mineralization Inhibition Of Non-skeletal Tissue Mineralization Response To Sodium Phosphate ATP Export
Pathways		Miscellaneous transport and binding events
Drugs
Diseases		Craniometaphyseal dysplasia
GWAS		Asthma ( 31959851) Glaucoma ( 31959993 30054594) Glaucoma (primary open-angle) ( 33627673 29891935) Homeostasis model assessment of insulin resistance (dietary factor interaction) ( 24204828) Intraocular pressure ( 29785010 30054594 31959993) Response to fenofibrate (total cholesterol levels) ( 27002377) Type 2 diabetes ( 30054458 29632382 30297969 32499647) Type 2 diabetes (adjusted for BMI) ( 29632382) Type 2 diabetes (time to event) ( 32589924) Urate levels (BMI interaction) ( 25811787)
Interacting Genes		2 interacting genes: APOE RPSA
Entrez ID		56172
HPRD ID		05509
Ensembl ID		ENSG00000154122
Uniprot IDs		Q9HCJ1
PDB IDs
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Phospholipid Efflux Negative Regulation Of Postsynaptic Membrane Organization Positive Regulation Of Lipid Transport Across Blood-brain Barrier Negative Regulation Of Lipid Transport Across Blood-brain Barrier Regulation Of Cellular Response To Very-low-density Lipoprotein Particle Stimulus Metal Chelating Activity Intermediate-density Lipoprotein Particle Clearance Positive Regulation Of Presynaptic Membrane Organization Chylomicron Remnant Lipid Transport Involved In Lipid Storage Lipoprotein Particle Positive Regulation Of Neurofibrillary Tangle Assembly Discoidal High-density Lipoprotein Particle Intermediate-density Lipoprotein Particle Regulation Of Postsynaptic Membrane Organization Positive Regulation Of Lipoprotein Transport Negative Regulation Of Dendritic Spine Maintenance Very-low-density Lipoprotein Particle Receptor Binding Positive Regulation Of Low-density Lipoprotein Particle Receptor Catabolic Process Very-low-density Lipoprotein Particle Clearance Multivesicular Body, Internal Vesicle Positive Regulation Of Phospholipid Efflux Positive Regulation Of Amyloid Fibril Formation AMPA Glutamate Receptor Clustering NMDA Glutamate Receptor Clustering Positive Regulation Of Inclusion Body Assembly Triglyceride-rich Lipoprotein Particle Clearance Positive Regulation Of Dendritic Spine Maintenance Regulation Of Plasma Lipoprotein Particle Levels Chylomicron Remnant Clearance Laminin Receptor Activity Regulation Of Neurofibrillary Tangle Assembly Lipoprotein Biosynthetic Process Phosphatidylcholine-sterol O-acyltransferase Activator Activity Regulation Of Low-density Lipoprotein Particle Receptor Catabolic Process Lipoprotein Particle Binding Virion Assembly Very-low-density Lipoprotein Particle Remodeling Positive Regulation Of Amyloid-beta Clearance Cholesterol Catabolic Process Negative Regulation Of Cholesterol Biosynthetic Process Protein Import High-density Lipoprotein Particle Clearance Negative Regulation Of Cholesterol Metabolic Process Nitric Oxide-cGMP-mediated Signaling Negative Regulation Of Dendritic Spine Development Positive Regulation Of Receptor Catabolic Process Triglyceride-rich Lipoprotein Particle Remodeling High-density Lipoprotein Particle Assembly Response To Caloric Restriction
Tagcloud ?