ACSS2

Gene Name		acyl-CoA synthetase short-chain family member 2
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleoplasm Cytoplasm Cytosol Intracellular Membrane-bounded Organelle
	Molecular Function	Acetate-CoA Ligase Activity ATP Binding AMP Binding
	Biological Process	Ethanol Oxidation Xenobiotic Metabolic Process Lipid Biosynthetic Process Acetate Biosynthetic Process Acetyl-CoA Biosynthetic Process From Acetate Propionate Biosynthetic Process Small Molecule Metabolic Process
Pathways		Defective CYP2R1 causes Rickets vitamin D-dependent 1B (VDDR1B) Defective FMO3 causes Trimethylaminuria (TMAU) Defective TBXAS1 causes Ghosal hematodiaphyseal dysplasia (GHDD) Defective CYP11A1 causes Adrenal insufficiency, congenital, with 46,XY sex reversal (AICSR) Defective CYP27A1 causes Cerebrotendinous xanthomatosis (CTX) Defective CYP11B1 causes Adrenal hyperplasia 4 (AH4) Defective CYP26B1 causes Radiohumeral fusions with other skeletal and craniofacial anomalies (RHFCA) Ethanol oxidation Metabolic disorders of biological oxidation enzymes Defective CYP1B1 causes Glaucoma Defective CYP27B1 causes Rickets vitamin D-dependent 1A (VDDR1A) Phase 1 - Functionalization of compounds Defective CYP17A1 causes Adrenal hyperplasia 5 (AH5) Defective CYP19A1 causes Aromatase excess syndrome (AEXS) Defective CYP7B1 causes Spastic paraplegia 5A, autosomal recessive (SPG5A) and Congenital bile acid synthesis defect 3 (CBAS3) Defective CYP4F22 causes Ichthyosis, congenital, autosomal recessive 5 (ARCI5) Defective CYP26C1 causes Focal facial dermal dysplasia 4 (FFDD4) Defective CYP24A1 causes Hypercalcemia, infantile (HCAI) Defective CYP2U1 causes Spastic paraplegia 56, autosomal recessive (SPG56) Defective MAOA causes Brunner syndrome (BRUNS) Defective CYP11B2 causes Corticosterone methyloxidase 1 deficiency (CMO-1 deficiency) Defective CYP21A2 causes Adrenal hyperplasia 3 (AH3) Biological oxidations
Drugs		Adenosine monophosphate Adenosine triphosphate
Diseases
GWAS
Protein-protein Interactions		1 interactors: UPF1
Entrez ID		55902
HPRD ID		12053
Ensembl ID		ENSG00000131069
Uniprot IDs		B3KUV2 Q4G0E8 Q6DKJ3 Q96FY7 Q9NR19
PDB IDs
Enriched GO Terms of Interacting Partners?		Histone MRNA Catabolic Process Dosage Compensation By Inactivation Of X Chromosome Regulation Of Translational Termination Dosage Compensation Histone MRNA Metabolic Process MRNA Export From Nucleus RNA Export From Nucleus Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Nuclear Export MRNA Transport Regulation Of Protein Complex Disassembly RNA Transport Nuclear-transcribed MRNA Catabolic Process RNA Localization MRNA Catabolic Process RNA Catabolic Process Regulation Of Gene Expression, Epigenetic Nucleocytoplasmic Transport Nuclear Transport Regulation Of Translation DNA Replication
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