ASH1L

Gene Name		ash1 (absent, small, or homeotic)-like (Drosophila)
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Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Chromosome Cytoplasm Golgi Apparatus Tight Junction Extracellular Vesicular Exosome
	Molecular Function	DNA Binding Chromatin Binding Zinc Ion Binding Histone Methyltransferase Activity (H3-K4 Specific)
	Biological Process	Negative Regulation Of Acute Inflammatory Response DNA Packaging Transcription From RNA Polymerase II Promoter Cell-cell Signaling Interleukin-6 Production Negative Regulation Of I-kappaB Kinase/NF-kappaB Signaling Negative Regulation Of MAPK Cascade Positive Regulation Of Transcription From RNA Polymerase II Promoter Histone H3-K4 Methylation
Pathways
Drugs
Diseases
GWAS
Protein-protein Interactions		2 interactors: HIST1H3A SMAD7
Entrez ID		55870
HPRD ID		06416
Ensembl ID		ENSG00000116539
Uniprot IDs		Q9NR48
PDB IDs		3MQM 3OPE
Enriched GO Terms of Interacting Partners?		Regulation Of Ventricular Cardiac Muscle Cell Membrane Depolarization Negative Regulation Of Transcription By Competitive Promoter Binding DNA Replication-dependent Nucleosome Assembly Negative Regulation Of Pathway-restricted SMAD Protein Phosphorylation Pathway-restricted SMAD Protein Phosphorylation DNA Methylation On Cytosine Cellular Protein Complex Localization Chromatin Silencing At RDNA Response To Laminar Fluid Shear Stress Negative Regulation Of Peptidyl-threonine Phosphorylation Protein Complex Localization Negative Regulation Of Epithelial To Mesenchymal Transition Regulation Of Gene Silencing Regulation Of Activin Receptor Signaling Pathway Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Peptidyl-serine Phosphorylation Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Ventricular Septum Morphogenesis Negative Regulation Of Stem Cell Differentiation Chromatin Silencing Regulation Of Membrane Depolarization Response To Fluid Shear Stress Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Negative Regulation Of BMP Signaling Pathway Ventricular Cardiac Muscle Tissue Morphogenesis Adherens Junction Assembly Ventricular Cardiac Muscle Tissue Development Ventricular Septum Development Regulation Of Pathway-restricted SMAD Protein Phosphorylation Cardiac Muscle Tissue Morphogenesis Artery Morphogenesis Cardiac Septum Morphogenesis Regulation Of Epithelial To Mesenchymal Transition DNA Methylation Muscle Tissue Morphogenesis Negative Regulation Of Ubiquitin-protein Transferase Activity Artery Development Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Muscle Organ Morphogenesis Cardiac Ventricle Morphogenesis Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Positive Regulation Of Proteasomal Protein Catabolic Process Negative Regulation Of Gene Expression, Epigenetic Regulation Of Cardiac Muscle Contraction BMP Signaling Pathway Cellular Component Assembly Cardiac Septum Development Regulation Of BMP Signaling Pathway
Tagcloud ?		arid1a atlas broadly chd6 colorectal concordant copy ep300 ep400 exome gains hypermutation mismatch mll2 mll3 nonhypermutated prdm2 preexisting profiled proofreading resembled seq signatures silico srcap tgfbeta trrap uncertain validating