METTL2B

Description		methyltransferase 2B, tRNA N3-cytidine
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm
	Molecular Function	Protein Binding Methyltransferase Activity RNA Methyltransferase Activity S-adenosylmethionine-dependent Methyltransferase Activity TRNA (cytidine) Methyltransferase Activity Transferase Activity TRNA (cytidine-3-)-methyltransferase Activity
	Biological Process	TRNA Metabolic Process TRNA Processing TRNA Methylation Methylation
Pathways
Drugs
Diseases
GWAS		Lean body mass ( 28552196) Treatment resistant depression ( 30468137)
Interacting Genes		3 interacting genes: APP PSEN1 PSEN2
Entrez ID		55798
HPRD ID		09705
Ensembl ID		ENSG00000165055
Uniprot IDs		Q6P1Q9
PDB IDs
Enriched GO Terms of Interacting Partners?		Synaptic Membrane Positive Regulation Of Amyloid Fibril Formation Growth Factor Receptor Binding Notch Signaling Pathway Astrocyte Activation Involved In Immune Response Aspartic Endopeptidase Activity, Intramembrane Cleaving Gamma-secretase Complex Notch Receptor Processing Amyloid-beta Formation Neuron Projection Maintenance Regulation Of Amyloid Fibril Formation Astrocyte Activation Amyloid Precursor Protein Catabolic Process Positive Regulation Of Glycolytic Process Membrane Protein Ectodomain Proteolysis Amyloid-beta Metabolic Process Amyloid Precursor Protein Metabolic Process Early Endosome Membrane Protein Proteolysis Inorganic Ion Homeostasis Positive Regulation Of ATP Metabolic Process Dendritic Shaft Neuron Projection Organization Monoatomic Cation Homeostasis Monoatomic Ion Homeostasis Cellular Response To Amyloid-beta Regulation Of Glycolytic Process Response To Amyloid-beta Regulation Of Carbohydrate Catabolic Process Regulation Of ATP Metabolic Process Regulation Of Purine Nucleotide Metabolic Process Protein-containing Complex Positive Regulation Of Tumor Necrosis Factor Production Chemical Homeostasis Positive Regulation Of Tumor Necrosis Factor Superfamily Cytokine Production Memory Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Myeloid Leukocyte Activation Negative Regulation Of Core Promoter Binding Regulation Of Generation Of Precursor Metabolites And Energy Presynaptic Membrane Synaptic Vesicle Growth Cone Regulation Of Postsynapse Organization Regulation Of Calcium Ion Transmembrane Transport Regulation Of Protein Localization To Nucleus
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