HHAT

Description		hedgehog acyltransferase
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GO Annotations	Cellular Component	Golgi Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Membrane
	Molecular Function	Nucleotide Binding Protein Binding GTP Binding O-acyltransferase Activity Palmitoyltransferase Activity Transferase Activity Acyltransferase Activity
	Biological Process	Smoothened Signaling Pathway N-terminal Peptidyl-L-cysteine N-palmitoylation Protein Modification Process
Pathways		Hedgehog ligand biogenesis HHAT G278V doesn't palmitoylate Hh-Np
Drugs
Diseases
GWAS		Alopecia areata ( 25608926) Ankylosing spondylitis ( 23749187) Body mass index (change over time) in chronic obstructive pulmonary disease ( 28044437) Body mass index (change over time) in lung cancer or chronic obstructive pulmonary disease ( 28044437) Cardiovascular disease in hypertension (ACE inhibitor interaction) ( 26516778) Heel bone mineral density ( 28869591 30598549) Intake of total sugars ( 31005972) Mosquito bite size ( 28199695) Neurofibrillary tangles ( 31497858) Obsessive-compulsive traits ( 33531474) Post bronchodilator FEV1/FVC ratio in smoking ( 30068317) Post bronchodilator percent predicted FEV1 in smoking ( 30068317) Schizophrenia ( 23142968) Triglyceride levels ( 32203549)
Interacting Genes		1 interacting genes: SDCBP
Entrez ID		55733
HPRD ID		12041
Ensembl ID		ENSG00000054392
Uniprot IDs		B7Z5N1 Q5VTY9
PDB IDs		6P64 6UJO 6UJQ 6UK2 6UK4 7MHY 7MHZ 7Q1U 7Q6Z 7URF
Enriched GO Terms of Interacting Partners?		Interleukin-5 Receptor Binding Interleukin-5 Receptor Complex Positive Regulation Of Extracellular Exosome Assembly Syndecan Binding Regulation Of Extracellular Exosome Assembly Substrate-dependent Cell Migration, Cell Extension Negative Regulation Of Receptor Internalization Positive Regulation Of Exosomal Secretion Regulation Of Exosomal Secretion Cytoskeletal Anchor Activity Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Receptor-mediated Endocytosis Frizzled Binding Protein Sequestering Activity Protein Targeting To Membrane Azurophil Granule Lumen Regulation Of Receptor Internalization Extracellular Vesicle Negative Regulation Of Endocytosis Positive Regulation Of Exocytosis Positive Regulation Of Epithelial To Mesenchymal Transition Phosphatidylinositol-4,5-bisphosphate Binding Ras Protein Signal Transduction Positive Regulation Of Organelle Assembly Positive Regulation Of JNK Cascade Melanosome Positive Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of Epithelial To Mesenchymal Transition Regulation Of Receptor-mediated Endocytosis Blood Microparticle Regulation Of JNK Cascade Positive Regulation Of Cell Growth Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway
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