WDR11

Description		WD repeat domain 11
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GO Annotations	Cellular Component	Nucleus Cytoplasm Lysosomal Membrane Golgi Apparatus Trans-Golgi Network Cytosol Cytoskeleton Plasma Membrane Cilium Axoneme Microtubule Cytoskeleton Membrane Cytoplasmic Vesicle Ciliary Basal Body Cell Projection
	Molecular Function	Protein Binding
	Biological Process	Intracellular Protein Transport Heart Development Regulation Of Smoothened Signaling Pathway Multicellular Organism Growth Cilium Assembly Head Development Vesicle Tethering To Golgi
Pathways		RHOH GTPase cycle
Drugs
Diseases
GWAS		Adiponectin levels ( 24105470) Anorexia nervosa ( 29155802) Apolipoprotein A1 levels ( 32203549) Benign prostatic hyperplasia and lower urinary tract symptoms ( 30410027) Coronary artery disease ( 32469254) High density lipoprotein cholesterol levels ( 33339817) Obesity-related traits ( 23251661) Prostate cancer ( 31562322) Prostate-specific antigen levels ( 28139693 30410027) Prostate-specific antigen levels (conditioned on lead SNPs) ( 28139693) Type 2 diabetes ( 30718926 32499647) Type 2 diabetes (adjusted for BMI) ( 30297969) Vaginal microbiome composition (L. iners) ( 32723796)
Interacting Genes		1 interacting genes: FOXP1
Entrez ID		55717
HPRD ID		16218
Ensembl ID		ENSG00000120008
Uniprot IDs		Q9BZH6
PDB IDs		8XFB 8Z9M
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Interleukin-21 Production Monocyte Activation Regulation Of Defense Response To Bacterium Positive Regulation Of Hydrogen Peroxide-mediated Programmed Cell Death Negative Regulation Of B Cell Apoptotic Process Osteoclast Development Negative Regulation Of Androgen Receptor Signaling Pathway Striatum Development Positive Regulation Of B Cell Receptor Signaling Pathway Endothelial Cell Activation Regulation Of Chemokine (C-X-C Motif) Ligand 2 Production Regulation Of Monocyte Differentiation T Follicular Helper Cell Differentiation Core Promoter Sequence-specific DNA Binding Negative Regulation Of Cell Growth Involved In Cardiac Muscle Cell Development Regulation Of Macrophage Colony-stimulating Factor Production Regulation Of Endothelial Tube Morphogenesis Regulation Of B Cell Apoptotic Process Regulation Of Cell Growth Involved In Cardiac Muscle Cell Development Regulation Of B Cell Receptor Signaling Pathway Negative Regulation Of Cardiac Muscle Tissue Growth Nuclear Androgen Receptor Binding Positive Regulation Of Antigen Receptor-mediated Signaling Pathway Negative Regulation Of Striated Muscle Cell Differentiation T-helper Cell Differentiation Negative Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Negative Regulation Of Muscle Hypertrophy Response To Testosterone Negative Regulation Of Lymphocyte Apoptotic Process Negative Regulation Of Organ Growth Regulation Of Androgen Receptor Signaling Pathway Negative Regulation Of Cardiac Muscle Hypertrophy T Cell Differentiation Involved In Immune Response Osteoclast Differentiation CD4-positive, Alpha-beta T Cell Differentiation T Cell Activation Involved In Immune Response Regulation Of Heart Growth Macrophage Activation Alpha-beta T Cell Differentiation Forebrain Development Regulation Of Lymphocyte Apoptotic Process CD4-positive, Alpha-beta T Cell Activation Regulation Of Morphogenesis Of An Epithelium Myeloid Cell Development Negative Regulation Of Muscle Cell Differentiation Regulation Of Interleukin-12 Production Negative Regulation Of Leukocyte Apoptotic Process Regulation Of Cardiac Muscle Hypertrophy Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Positive Regulation Of Smooth Muscle Cell Proliferation
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