KBTBD4

Description		kelch repeat and BTB domain containing 4
Image
GO Annotations	Cellular Component
	Molecular Function	Protein Binding
	Biological Process
Pathways
Drugs
Diseases
GWAS		Alzheimer's disease or fasting glucose levels (pleiotropy) ( 30805717) Bipolar disorder ( 31043756) Body fat distribution (arm fat ratio) ( 30664634) Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Brain morphology (MOSTest) ( 32665545) Fruit consumption ( 32066663) Loneliness ( 29970889) Loneliness (MTAG) ( 29970889) Mood instability ( 31168069) Neuroticism ( 29255261) Sleep duration (short sleep) ( 30846698)
Novel Interacting Genes		1 novel interacting genes: AMBRA1
Interacting Genes		4 interacting genes: MPP3 PTEN TRIM55 TRIM63
Entrez ID		55709
HPRD ID		13757
Ensembl ID		ENSG00000123444
Uniprot IDs		Q9NVX7
PDB IDs		2EQX 8VOJ 8VPQ 8VRT 9DTG 9DTQ
Enriched GO Terms of Interacting Partners?		PDZ Domain Binding Protein Modification Process Negative Regulation Of Synaptic Vesicle Clustering Phosphatidylinositol-3,4-bisphosphate 3-phosphatase Activity Negative Regulation Of Keratinocyte Migration Inositol-1,3,4,5-tetrakisphosphate 3-phosphatase Activity Response To Electrical Stimulus Inositol-1,3,4,5,6-pentakisphosphate 3-phosphatase Activity Positive Regulation Of Free Ubiquitin Chain Polymerization Protein Modification By Small Protein Conjugation Protein Ubiquitination Response To Electrical Stimulus Involved In Regulation Of Muscle Adaptation Regulation Of G1/S Transition Of Mitotic Cell Cycle Central Nervous System Myelin Maintenance Rhythmic Synaptic Transmission Negative Regulation Of Phosphate Metabolic Process Negative Regulation Of Wound Healing, Spreading Of Epidermal Cells Regulation Of Cell Cycle G1/S Phase Transition Post-translational Protein Modification Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase Activity Myelin Sheath Adaxonal Region Phosphatidylinositol Phosphate Phosphatase Activity Skeletal Muscle Atrophy Negative Regulation Of Peptidyl-serine Phosphorylation Regulation Of Synaptic Vesicle Clustering Postsynaptic Density Assembly Response To Mitochondrial Depolarisation Diapedesis Skeletal Muscle Adaptation Striated Muscle Atrophy Neuron-neuron Synaptic Transmission Positive Regulation Of Intracellular Signal Transduction Negative Regulation Of Cell Size Anaphase-promoting Complex Binding Forebrain Morphogenesis Presynaptic Membrane Assembly Protein Polyubiquitination Muscle Atrophy Locomotor Rhythm Protein Metabolic Process Cellular Response To Electrical Stimulus Ubiquitin Ligase Activator Activity Spindle Assembly Involved In Female Meiosis Regulation Of Mitotic Cell Cycle Phase Transition Postsynaptic Specialization Assembly Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Maternal Behavior Presynaptic Membrane Organization Schmidt-Lanterman Incisure Negative Regulation Of Excitatory Postsynaptic Potential
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