SLC39A4

Description		solute carrier family 39 member 4
Image		No pdb structure
GO Annotations	Cellular Component	Endosome Plasma Membrane Membrane Apical Plasma Membrane Cytoplasmic Vesicle Recycling Endosome Membrane
	Molecular Function	Zinc Ion Transmembrane Transporter Activity Zinc Ion Binding Identical Protein Binding Metal Ion Binding Metal Ion Transmembrane Transporter Activity Zinc Ion Sensor Activity Monoatomic Cation:bicarbonate Symporter Activity Zinc Ion Sequestering Activity
	Biological Process	Monoatomic Ion Transport Zinc Ion Transport Intracellular Zinc Ion Homeostasis Bicarbonate Transport Metal Ion Transport Intracellular Monoatomic Cation Homeostasis Cellular Response To Zinc Ion Starvation Transmembrane Transport Zinc Ion Transmembrane Transport Zinc Ion Import Across Plasma Membrane
Pathways		Zinc influx into cells by the SLC39 gene family Defective SLC39A4 causes acrodermatitis enteropathica, zinc-deficiency type (AEZ)
Drugs
Diseases		Acrodermatitis enteropathica (AEZ)
GWAS		Height ( 28552196) Liver enzyme levels (alkaline phosphatase) ( 33972514)
Interacting Genes		1 interacting genes: ADRB2
Entrez ID		55630
HPRD ID		06137
Ensembl ID		ENSG00000147804
Uniprot IDs		Q6P5W5 Q9NX22
PDB IDs
Enriched GO Terms of Interacting Partners?		Regulation Of Systemic Arterial Blood Pressure By Norepinephrine-epinephrine Positive Regulation Of Mini Excitatory Postsynaptic Potential Response To Psychosocial Stress Norepinephrine-epinephrine-mediated Vasodilation Involved In Regulation Of Systemic Arterial Blood Pressure Beta-adrenergic Receptor Activity Norepinephrine Binding Positive Regulation Of Lipophagy AMPA Selective Glutamate Receptor Signaling Pathway Beta2-adrenergic Receptor Activity Positive Regulation Of Autophagosome Maturation Heat Generation Adrenergic Receptor Activity Diet Induced Thermogenesis Adenylate Cyclase Binding Negative Regulation Of Smooth Muscle Contraction Negative Regulation Of Multicellular Organism Growth Adenylate Cyclase-activating Adrenergic Receptor Signaling Pathway Regulation Of Autophagosome Maturation Positive Regulation Of CAMP/PKA Signal Transduction Negative Regulation Of Muscle Contraction Neuronal Dense Core Vesicle Adrenergic Receptor Signaling Pathway Negative Regulation Of Systemic Arterial Blood Pressure Adaptive Thermogenesis Bone Resorption Regulation Of Systemic Arterial Blood Pressure Mediated By A Chemical Signal Brown Fat Cell Differentiation Ionotropic Glutamate Receptor Signaling Pathway Positive Regulation Of Excitatory Postsynaptic Potential Temperature Homeostasis Positive Regulation Of Protein-containing Complex Disassembly Regulation Of CAMP/PKA Signal Transduction Potassium Channel Regulator Activity Ligand-gated Ion Channel Signaling Pathway Regulation Of Systemic Arterial Blood Pressure Response To Cold Positive Regulation Of Bone Mineralization Glutamate Receptor Signaling Pathway Cellular Response To Amyloid-beta Modulation Of Excitatory Postsynaptic Potential Negative Regulation Of Blood Pressure Positive Regulation Of Biomineral Tissue Development Smooth Muscle Contraction Vasodilation Negative Regulation Of G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Ossification Endosome To Lysosome Transport Regulation Of Smooth Muscle Contraction Response To Amyloid-beta Regulation Of Multicellular Organism Growth
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