SLC30A10

Description		solute carrier family 30 member 10
Image		No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Endosome Early Endosome Golgi Apparatus Plasma Membrane Synaptic Vesicle Membrane Early Endosome Membrane Recycling Endosome Recycling Endosome Membrane
	Molecular Function	Manganese Ion Transmembrane Transporter Activity Zinc Ion Transmembrane Transporter Activity Protein Binding Monoatomic Cation Transmembrane Transporter Activity Antiporter Activity Calcium:manganese Antiporter Activity
	Biological Process	Monoatomic Ion Transport Monoatomic Cation Transport Manganese Ion Transport Zinc Ion Transport Intracellular Copper Ion Homeostasis Intracellular Zinc Ion Homeostasis Epidermal Growth Factor Receptor Signaling Pathway Detoxification Of Zinc Ion Intracellular Manganese Ion Homeostasis Manganese Ion Homeostasis Transmembrane Transport Zinc Ion Import Into Organelle Positive Regulation Of ERK1 And ERK2 Cascade Zinc Ion Transmembrane Transport Manganese Ion Export Across Plasma Membrane Cellular Response To Angiotensin
Pathways		Metal ion SLC transporters
Drugs
Diseases
GWAS		Adult body size ( 32376654) Alanine aminotransferase levels ( 34315874 33547301) Apolipoprotein A1 levels ( 32203549) Aspartate aminotransferase levels ( 34315874) Chronic obstructive pulmonary disease ( 30804561) Extrahepatic cholangiocarcinoma ( 34315874) Femur bone mineral density x serum urate levels interaction ( 34046847) HDL cholesterol levels ( 32203549) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Hip circumference adjusted for BMI ( 34021172) Hip index ( 34021172) Immature fraction of reticulocytes ( 32888494) Liver fibrosis and steatohepatitis severity (MRI cT1 measure) ( 32247823) Nose size ( 27182965) Osteoarthritis ( 30664745) Pulse pressure ( 30224653) Red cell distribution width ( 32888494) Refractive error ( 32231278) Reticulocyte count ( 32888494 27863252) Reticulocyte fraction of red cells ( 32888494 27863252) Sexual dimorphism in anthropometric traits ( 23754948) Total body bone mineral density ( 29304378) Triglyceride levels ( 32203549 32154731) Urinary electrolytes (magnesium/calcium ratio) ( 27915449) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172 26426971) Waist-to-hip ratio adjusted for BMI (age <50) ( 26426971) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
Novel Interacting Genes		1 novel interacting genes: MTARC1
Interacting Genes
Entrez ID		55532
HPRD ID		15367
Ensembl ID		ENSG00000196660
Uniprot IDs		A0A8Q3WLF3 B3KR19 Q6XR72
PDB IDs
Enriched GO Terms of Interacting Partners?		Nitric-oxide Synthase Complex Nitrate Reductase Activity Oxidoreductase Activity, Acting On Other Nitrogenous Compounds As Donors Detoxification Of Nitrogen Compound Cellular Detoxification Of Nitrogen Compound Nitrate Metabolic Process Molybdenum Ion Binding Nitrite Reductase Activity Molybdopterin Cofactor Binding Nitrite Reductase (NO-forming) Activity Nitric Oxide Biosynthetic Process Nitric Oxide Metabolic Process Reactive Nitrogen Species Metabolic Process Pyridoxal Phosphate Binding Cellular Detoxification Mitochondrial Outer Membrane Catalytic Activity Oxidoreductase Activity
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