DHTKD1

Description		dehydrogenase E1 and transketolase domain containing 1
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GO Annotations	Cellular Component	Mitochondrion Mitochondrial Matrix Oxoadipate Dehydrogenase Complex
	Molecular Function	Oxoglutarate Dehydrogenase (succinyl-transferring) Activity Protein Binding Oxidoreductase Activity Oxidoreductase Activity, Acting On The Aldehyde Or Oxo Group Of Donors, Disulfide As Acceptor Thiamine Pyrophosphate Binding 2-oxoadipate Dehydrogenase Activity
	Biological Process	Hematopoietic Progenitor Cell Differentiation Generation Of Precursor Metabolites And Energy Glycolytic Process
Pathways		OADH complex synthesizes glutaryl-CoA from 2-OA
Drugs
Diseases
GWAS		Urinary metabolite levels in chronic kidney disease ( 31959995)
Interacting Genes		1 interacting genes: BMAL1
Entrez ID		55526
HPRD ID		09917
Ensembl ID		ENSG00000181192
Uniprot IDs		Q96HY7
PDB IDs		5RVW 5RVX 5RVY 5RVZ 5RW0 5RW1 6SY1 6U3J
Enriched GO Terms of Interacting Partners?		Oxidative Stress-induced Premature Senescence Positive Regulation Of Protein Acetylation CLOCK-BMAL Transcription Complex Stress-induced Premature Senescence Negative Regulation Of Nuclear Receptor-mediated Glucocorticoid Signaling Pathway Aryl Hydrocarbon Receptor Binding Regulation Of Type B Pancreatic Cell Development Aryl Hydrocarbon Receptor Complex Positive Regulation Of Skeletal Muscle Cell Differentiation Chromatoid Body Response To Redox State Positive Regulation Of Circadian Rhythm Regulation Of Skeletal Muscle Cell Differentiation Regulation Of Hair Cycle Negative Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Hsp90 Protein Binding Regulation Of Cellular Senescence Negative Regulation Of Cold-induced Thermogenesis Negative Regulation Of Fat Cell Differentiation E-box Binding Cellular Senescence Circadian Regulation Of Gene Expression Energy Homeostasis Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Negative Regulation Of TOR Signaling Positive Regulation Of Canonical Wnt Signaling Pathway PML Body Regulation Of Circadian Rhythm Regulation Of Fat Cell Differentiation Transcription Coregulator Activity Circadian Rhythm Regulation Of TOR Signaling Regulation Of Cold-induced Thermogenesis Positive Regulation Of Wnt Signaling Pathway Regulation Of Insulin Secretion Protein Dimerization Activity DNA-binding Transcription Factor Binding Regulation Of Peptide Hormone Secretion
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