SLC35C1

Description		solute carrier family 35 member C1
Image		No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Golgi Apparatus Membrane
	Molecular Function	GDP-fucose Transmembrane Transporter Activity Protein Binding Antiporter Activity
	Biological Process	GDP-fucose Import Into Golgi Lumen GDP-L-fucose Biosynthetic Process 'de Novo' GDP-L-fucose Biosynthetic Process GDP-L-fucose Salvage Negative Regulation Of Notch Signaling Pathway
Pathways		Defective SLC35C1 causes congenital disorder of glycosylation 2C (CDG2C) GDP-fucose biosynthesis Transport of nucleotide sugars
Drugs
Diseases		Congenital disorders of glycosylation (CDG) type II Leukocyte adhesion deficiency (LAD), including the following four diseases: Leukocyte adhesion deficiency (I); Leukocyte adhesion deficiency (II); Leukocyte adhesion deficiency (III); LAD with Rac2 deficiency
GWAS		Axial length ( 24144296) Diastolic blood pressure ( 26969751) Visceral fat ( 22589738)
Novel Interacting Genes		1 novel interacting genes: AMBRA1
Interacting Genes
Entrez ID		55343
HPRD ID		09324
Ensembl ID		ENSG00000181830
Uniprot IDs		B3KQH0 Q96A29
PDB IDs
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Free Ubiquitin Chain Polymerization Response To Mitochondrial Depolarisation Mitophagy Protein Phosphatase Activator Activity Neural Tube Development Cul4-RING E3 Ubiquitin Ligase Complex Positive Regulation Of Mitophagy Positive Regulation Of Regulatory T Cell Differentiation GTPase Binding Regulation Of Cardiac Muscle Cell Apoptotic Process Negative Regulation Of Striated Muscle Cell Apoptotic Process Positive Regulation Of Autophagy Of Mitochondrion Regulation Of Regulatory T Cell Differentiation Regulation Of Autophagy Of Mitochondrion Negative Regulation Of Cardiac Muscle Cell Apoptotic Process Negative Regulation Of Muscle Cell Apoptotic Process Regulation Of Mitophagy Ubiquitin-like Ligase-substrate Adaptor Activity Positive Regulation Of Protein Polymerization Autophagosome Positive Regulation Of Macroautophagy Cell Cycle G1/S Phase Transition Protein Phosphatase Binding Autophagosome Organization G1/S Transition Of Mitotic Cell Cycle Autophagosome Assembly Autophagy Of Mitochondrion Phagocytic Vesicle Positive Regulation Of T Cell Differentiation Axoneme Mitotic Cell Cycle Phase Transition Vacuole Organization Positive Regulation Of Lymphocyte Differentiation Cellular Response To Starvation Intracellular Membrane-bounded Organelle Positive Regulation Of Autophagy Macroautophagy Positive Regulation Of Leukocyte Differentiation Cell Cycle Phase Transition Regulation Of Macroautophagy Negative Regulation Of Neuron Apoptotic Process Regulation Of Cell Cycle G1/S Phase Transition Regulation Of T Cell Differentiation Regulation Of G1/S Transition Of Mitotic Cell Cycle Positive Regulation Of Protein-containing Complex Assembly Mitochondrial Outer Membrane Tube Development Response To Starvation Regulation Of Lymphocyte Differentiation Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
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