LSG1

Description		large 60S subunit nuclear export GTPase 1
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Endoplasmic Reticulum Cytosol Cajal Body Membrane Nuclear Body
	Molecular Function	Nucleotide Binding GTPase Activity GTP Binding Hydrolase Activity
	Biological Process	Ribosomal Subunit Export From Nucleus Protein Transport Nuclear Export
Pathways
Drugs
Diseases
GWAS		Blood osmolality (transformed sodium) ( 28360221) Dental caries (decayed, missing and filled teeth) ( 31533690) Dental caries (decayed, missing and filled tooth surfaces) ( 31533690) Pursuit maintenance gain ( 29064472)
Interacting Genes		1 interacting genes: PRKN
Entrez ID		55341
HPRD ID		07748
Ensembl ID		ENSG00000041802
Uniprot IDs		Q9H089
PDB IDs		6LSR
Enriched GO Terms of Interacting Partners?		Parkin-FBXW7-Cul1 Ubiquitin Ligase Complex Positive Regulation Of Retrograde Transport, Endosome To Golgi Negative Regulation Of Glucokinase Activity Regulation Protein Catabolic Process At Presynapse Negative Regulation Of Intralumenal Vesicle Formation Mitochondrion To Lysosome Vesicle-mediated Transport Mitochondrion-derived Vesicle F-box Domain Binding Positive Regulation Of Protein Linear Polyubiquitination Negative Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Cellular Response To Hydrogen Sulfide Negative Regulation Of Spontaneous Neurotransmitter Secretion Response To Curcumin Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Mitochondrial Fusion Cellular Response To L-glutamine Response To Hydrogen Sulfide Negative Regulation Of Exosomal Secretion Lewy Body Regulation Of Spontaneous Synaptic Transmission Type 2 Mitophagy Dopamine Uptake Involved In Synaptic Transmission Negative Regulation Of Mitochondrial Fission Regulation Of Endosome Organization Positive Regulation Of Mitochondrial Membrane Potential Aggresome Assembly Positive Regulation Of Neurotransmitter Uptake Regulation Of Synaptic Vesicle Transport Free Ubiquitin Chain Polymerization Cellular Response To Dopamine Negative Regulation Of Mitochondrial Fusion Negative Regulation Of Neurotransmitter Secretion Regulation Of Retrograde Transport, Endosome To Golgi Response To Dopamine Negative Regulation Of Synaptic Transmission, Glutamatergic Cellular Response To L-glutamate Inclusion Body Assembly Cellular Response To Manganese Ion Positive Regulation Of Membrane Potential Positive Regulation Of Type 2 Mitophagy Catecholamine Uptake Dopamine Uptake Mitochondrial Fragmentation Involved In Apoptotic Process Negative Regulation Of Excitatory Postsynaptic Potential Mitochondrial Fission Negative Regulation Of Oxidative Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Host-mediated Suppression Of Viral Genome Replication Dopaminergic Synapse Cellular Response To Toxic Substance Protein K29-linked Ubiquitination
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