ACER3

Name	alkaline ceramidase 3
Structure
Interactors	1 interactors: MLH1
GO Annotations	Cellular Component	Golgi Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Membrane
	Molecular Function	Calcium Ion Binding Zinc Ion Binding Hydrolase Activity Hydrolase Activity, Acting On Carbon-nitrogen (but Not Peptide) Bonds, In Linear Amides N-acylsphingosine Amidohydrolase Activity Metal Ion Binding
	Biological Process	Lipid Metabolic Process Sphingolipid Metabolic Process Ceramide Metabolic Process Inflammatory Response Positive Regulation Of Cell Population Proliferation Myelination Regulation Of Programmed Cell Death Sphingosine Biosynthetic Process Ceramide Catabolic Process Phytosphingosine Biosynthetic Process
Pathways	Sphingolipid catabolism
GWAS	Alzheimer's disease ( 33074286 )
Entrez ID	55331
HPRD ID	17844
Ensembl ID	ENSG00000078124
Uniprot IDs	A0A7P0T8K3 B7Z1R2 B7Z2Q2 B7Z2V2 Q9NUN7
PDB IDs	6G7O 6YXH
GO Terms Enriched among Interactors ?	Meiotic Spindle Midzone Assembly Meiotic Metaphase Chromosome Alignment Chiasma Late Recombination Nodule Meiotic Metaphase I Homologous Chromosome Alignment Guanine/thymine Mispair Binding Male Meiosis Chromosome Segregation Homologous Chromosome Segregation MutLalpha Complex Female Meiosis Chromosome Segregation Mismatch Repair Complex Negative Regulation Of Mitotic Recombination Positive Regulation Of Isotype Switching To IgA Isotypes MutSalpha Complex Binding Regulation Of Mitotic Recombination Meiotic Telomere Clustering Chromosome Localization To Nuclear Envelope Involved In Homologous Chromosome Segregation Telomere Localization Mismatched DNA Binding Positive Regulation Of Isotype Switching To IgG Isotypes Spindle Midzone Assembly Somatic Hypermutation Of Immunoglobulin Genes Meiotic Chromosome Segregation Somatic Diversification Of Immune Receptors Via Somatic Mutation Regulation Of Isotype Switching To IgG Isotypes Resolution Of Meiotic Recombination Intermediates ATP-dependent DNA Damage Sensor Activity Nuclear-transcribed MRNA Poly(A) Tail Shortening Isotype Switching Homologous Chromosome Pairing At Meiosis Positive Regulation Of Isotype Switching Somatic Diversification Of Immunoglobulins Involved In Immune Response Reciprocal Meiotic Recombination Synaptonemal Complex Somatic Recombination Of Immunoglobulin Genes Involved In Immune Response Mismatch Repair Somatic Recombination Of Immunoglobulin Gene Segments Condensed Chromosome Regulation Of Isotype Switching Nuclear Lumen Homologous Recombination Positive Regulation Of Immunoglobulin Mediated Immune Response Somatic Diversification Of Immunoglobulins Somatic Cell DNA Recombination Oogenesis Male Meiotic Nuclear Division Negative Regulation Of DNA Recombination Condensed Nuclear Chromosome Male Germ Cell Nucleus Nuclear Chromosome Segregation