SLC29A3

Description		solute carrier family 29 member 3
Image		No pdb structure
GO Annotations	Cellular Component	Mitochondrion Mitochondrial Outer Membrane Lysosome Lysosomal Membrane Endosome Golgi Apparatus Plasma Membrane Membrane Late Endosome Membrane Mitochondrial Membrane
	Molecular Function	Neurotransmitter Transmembrane Transporter Activity Nucleoside Transmembrane Transporter Activity Protein Binding Monoamine Transmembrane Transporter Activity Organic Cation Transmembrane Transporter Activity Nucleobase Transmembrane Transporter Activity Guanine Transmembrane Transporter Activity Uracil Transmembrane Transporter Activity Cytidine Transmembrane Transporter Activity Uridine Transmembrane Transporter Activity Transmembrane Transporter Activity
	Biological Process	Xenobiotic Metabolic Process Neurotransmitter Transport Serotonin Transport Nucleobase Transport Nucleoside Transport Cytidine Transport Uridine Transmembrane Transport Dopamine Transport Norepinephrine Transport Adenosine Transport Inosine Transport Nucleoside Transmembrane Transport Guanine Transmembrane Transport Uracil Transmembrane Transport Pyrimidine Nucleobase Transmembrane Transport Purine Nucleobase Transmembrane Transport
Pathways		Defective SLC29A3 causes histiocytosis-lymphadenopathy plus syndrome (HLAS) Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane Ribavirin ADME
Drugs
Diseases		Hyperpigmentation, cutaneous, with hypertrichosis, hepatosplenomegaly, heart anomalies, hearing loss, and hypogonadism; H syndrome
GWAS		Diisocyanate-induced asthma ( 25918132) Disease progression in age-related macular degeneration (adjusted for baseline) ( 29346644) Lymphocyte count ( 32888494) Obesity-related traits ( 23251661) Sleep duration ( 30531941) Systemic lupus erythematosus ( 23273568) Vitiligo ( 22951725) White blood cell count ( 32888494)
Interacting Genes		1 interacting genes: CREB3
Entrez ID		55315
HPRD ID		11570
Ensembl ID		ENSG00000198246
Uniprot IDs		A0A2R8YDR8 Q9BZD2
PDB IDs
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Deacetylase Activity CCR1 Chemokine Receptor Binding Release From Viral Latency CAMP Response Element Binding Protein Binding Induction Of Positive Chemotaxis Positive Regulation Of Monocyte Chemotaxis Negative Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Positive Chemotaxis Regulation Of Monocyte Chemotaxis Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Transcription Coregulator Binding Integrated Stress Response Signaling Negative Regulation Of Response To Endoplasmic Reticulum Stress Endoplasmic Reticulum Unfolded Protein Response Positive Regulation Of Mononuclear Cell Migration Response To Unfolded Protein Regulation Of Response To Endoplasmic Reticulum Stress Positive Regulation Of Leukocyte Chemotaxis Positive Regulation Of Calcium Ion Transport Negative Regulation Of Intrinsic Apoptotic Signaling Pathway Regulation Of Mononuclear Cell Migration Positive Regulation Of Leukocyte Migration Positive Regulation Of Chemotaxis Viral Process RNA Polymerase II Transcription Regulator Complex
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