FIGN

Description		fidgetin, microtubule severing factor
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Centrosome Cytoskeleton Microtubule Nuclear Matrix
	Molecular Function	Nucleotide Binding Protein Binding ATP Binding Microtubule Severing ATPase Activity ATP Hydrolysis Activity
	Biological Process	Microtubule Severing Cell Division
Pathways
Drugs
Diseases
GWAS		A body shape index ( 34021172) Age at first sexual intercourse ( 34211149) Blood pressure ( 21572416 21909110 24954895) BMI (adjusted for smoking behaviour) ( 28443625) BMI in non-smokers ( 28443625) Body mass index ( 25673413) Body mass index (joint analysis main effects and smoking interaction) ( 28443625) Chronic kidney disease ( 26831199) Coronary artery disease ( 33020668 32469254) Daytime nap ( 33568662) Diastolic blood pressure ( 28739976 27618452) Diastolic blood pressure (cigarette smoking interaction) ( 29455858) Diisocyanate-induced asthma ( 25918132) Folate pathway vitamin levels ( 19744961) General risk tolerance (MTAG) ( 30643258) Hip circumference adjusted for BMI ( 28552196) Hypertension ( 30487518) Immunoglobulin A vasculitis ( 28698626) Mean arterial pressure ( 26390057 29403010 30487518) Myocardial infarction ( 33532862) Platinum-induced myelosuppression in non-small cell lung cancer ( 25823687) Polycystic ovary syndrome (metabolic subtype) ( 32574161) PR interval ( 30046033 32439900) Pulse pressure ( 27841878 30487518 28739976) Response to antipsychotic treatment ( 19680635) Systolic blood pressure ( 29403010 28739976 26390057 27618447 27618452 28135244 27841878) Systolic blood pressure (cigarette smoking interaction) ( 29455858) Waist circumference adjusted for body mass index ( 34021172) Waist-hip index ( 34021172)
Interacting Genes		2 interacting genes: CHERP HGS
Entrez ID		55137
HPRD ID		07287
Ensembl ID		ENSG00000182263
Uniprot IDs		Q5HY92
PDB IDs
Enriched GO Terms of Interacting Partners?		Protein Transport To Vacuole Involved In Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Late Endosome To Vacuole Transport Via Multivesicular Body Sorting Pathway Negative Regulation Of Cell Population Proliferation ESCRT-0 Complex Multivesicular Body Membrane Negative Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Phagocytic Vesicle Lumen Multivesicular Body Organization Negative Regulation Of Receptor Signaling Pathway Via JAK-STAT Protein Targeting To Lysosome Late Endosome To Vacuole Transport Negative Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Regulation Of Exosomal Secretion Ubiquitin-like Protein Ligase Binding Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Multivesicular Body Assembly Negative Regulation Of Receptor Signaling Pathway Via STAT Positive Regulation Of Exosomal Secretion Regulation Of Calcineurin-NFAT Signaling Cascade Sarcoplasmic Reticulum Membrane Regulation Of Calcineurin-mediated Signaling Positive Regulation Of Calcineurin-NFAT Signaling Cascade Endosome Transport Via Multivesicular Body Sorting Pathway Membrane Fission Membrane Invagination Multivesicular Body Sorting Pathway Protein Localization To Lysosome Protein Targeting To Vacuole Positive Regulation Of Calcium-mediated Signaling Negative Regulation Of Sequestering Of Calcium Ion Release Of Sequestered Calcium Ion Into Cytosol Establishment Of Protein Localization To Vacuole Regulation Of MAP Kinase Activity Receptor Internalization Regulation Of Receptor Signaling Pathway Via JAK-STAT Positive Regulation Of Exocytosis Endocytic Recycling Regulation Of Cell Population Proliferation Endosome Organization
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