CDKAL1

Description		CDKAL1 threonylcarbamoyladenosine tRNA methylthiotransferase
Image		No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Rough Endoplasmic Reticulum Membrane
	Molecular Function	Catalytic Activity Protein Binding Transferase Activity Methylthiotransferase Activity TRNA (N(6)-L-threonylcarbamoyladenosine(37)-C(2))-methylthiotransferase Activity Metal Ion Binding Iron-sulfur Cluster Binding 4 Iron, 4 Sulfur Cluster Binding
	Biological Process	TRNA Modification TRNA Processing Biological_process TRNA Methylthiolation Maintenance Of Translational Fidelity
Pathways		tRNA modification in the nucleus and cytosol
Drugs
Diseases		Type II diabetes mellitus
GWAS		Acute insulin response ( 28490609) Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL) ( 28090653) Alzheimer disease and age of onset ( 26830138) Appendicular lean mass ( 33097823) Bipolar disorder ( 25827505) Birth weight ( 23202124 27680694 31043758) Bladder cancer ( 24163127) Blond vs. brown/black hair color ( 30531825) Blood glucose levels ( 31928498) Blood sugar levels ( 29403010) Body mass index ( 22344219 24861553 28892062 29381148) Body mass index (SNP x SNP interaction) ( 22344221) Breast cancer ( 29059683) Chloride levels ( 29403010) Cholesterol efflux capacity ( 29674289) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Cognitive function ( 25644384) Corrected insulin response ( 24699409) Corrected insulin response adjusted for insulin sensitivity index ( 24699409) Crohn's disease ( 18587394 21102463 28067908) Cutaneous malignant melanoma ( 26237428 32341527) Depression in smokers ( 30219690) Diabetes (gestational) ( 22233651) Endometrial cancer ( 27008869) Estimated glomerular filtration rate ( 31451708) Fasting blood glucose ( 25631608) Fasting glucose ( 34059833) Fasting glucose change (short-term) ( 31263163) Fasting plasma glucose ( 25187374) Femoral neck bone mineral density ( 22504420 29499414) Femur bone mineral density x serum urate levels interaction ( 34046847) General cognitive ability ( 29844566) Glucose homeostasis traits ( 25524916) Glycated hemoglobin levels ( 22290723 24647736 28898252 34059833) Glycemic traits ( 23575436) Hematological and biochemical traits ( 31902109) Hemoglobin A1c levels ( 29403010) Ileal carcinoids ( 21139019) Incremental insulin ( 24699409) Inflammatory bowel disease ( 28067908) Insulin disposition index ( 24699409) Insulin levels ( 24699409) Insulin levels adjusted for BMI ( 24699409) Insulin secretion rate ( 28490609) Insulin-related traits (multivariate analysis) ( 32002517) Lumbar spine bone mineral density ( 29499414) Mean corpuscular volume ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Medication use (drugs used in diabetes) ( 31015401) Melanoma ( 28212542) Metabolically unhealthy in normal weight ( 33500527) Metabolite levels ( 23823483) Mild obesity-related type 2 diabetes ( 34737425) Monocyte count ( 32888494) Neutrophil count ( 32888494) Nevus count or cutaneous melanoma ( 32341527) Obesity-related traits ( 23251661) Pancreatic beta-cell glucose sensitivity ( 32944759) Peak insulin response ( 28490609) Prevalent type 2 diabetes ( 28406950) Prostate cancer ( 25939597) Psoriasis vulgaris ( 26626624) Pulse pressure ( 30578418) Refractive error ( 32231278) Severe insulin-deficient type 2 diabetes ( 34737425) Systolic blood pressure ( 30224653 30578418 31928498) Thoracic aortic calcification levels ( 31659325) Triglyceride levels x SSRI defined daily dose interaction in schizophrenia or bipolar disorder ( 33824429) Type 2 diabetes ( 17460697 17463246 17463248 17463249 17554300 18372903 18711366 19401414 19734900 20581827 21490949 22693455 22885922 22961080 23945395 24509480 25483131 26818947 26961502 27189021 28869590 29358691 30054458 30297969 30718926 31118516 32499647 32794382) Type 2 diabetes or prostate cancer (pleiotropy) ( 33290408) Urate levels ( 31578528) White blood cell count ( 32888494)
Interacting Genes		3 interacting genes: LCK OGT TRIM54
Entrez ID		54901
HPRD ID		13022
Ensembl ID		ENSG00000145996
Uniprot IDs		Q5VV42
PDB IDs
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Gamma-delta T Cell Differentiation Positive Regulation Of Gamma-delta T Cell Activation Peptidyl-tyrosine Autophosphorylation CD8 Receptor Binding Phospholipase Activator Activity CD4 Receptor Binding CD27 Signaling Pathway Gamma-delta T Cell Differentiation Hemopoiesis Regulation Of Gamma-delta T Cell Differentiation Protein Antigen Binding NSL Complex Positive Regulation Of Transcription From RNA Polymerase II Promoter By Glucose Protein N-acetylglucosaminyltransferase Complex Non-canonical Inflammasome Complex Assembly Negative Regulation Of Non-canonical Inflammasome Complex Assembly Regulation Of Transcription By Glucose Positive Regulation Of Transcription By Glucose Carbon Catabolite Regulation Of Transcription Regulation Of Transcription From RNA Polymerase II Promoter By Glucose Protein O-acetylglucosaminyltransferase Activity T Cell Receptor Binding Positive Regulation Of Heterotypic Cell-cell Adhesion Intracellular Chemical Homeostasis Phosphatidylinositol 3-kinase Binding Positive Regulation Of T Cell Receptor Signaling Pathway Acetylglucosaminyltransferase Activity Regulation Of Neurotransmitter Receptor Localization To Postsynaptic Specialization Membrane Gamma-delta T Cell Activation
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