CNTLN

Description		centlein
Image		No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Centrosome Centriole Cytosol Cytoskeleton Extracellular Exosome Sperm Head-tail Coupling Apparatus
	Molecular Function	Protein Binding Protein Kinase Binding Protein Domain Specific Binding Protein-macromolecule Adaptor Activity
	Biological Process	Spermatogenesis Single Fertilization Intracellular Protein Localization Centriole-centriole Cohesion Regulation Of Protein Localization Protein Localization To Organelle Protein-containing Complex Assembly
Pathways
Drugs
Diseases
GWAS		Amyotrophic lateral sclerosis (sporadic) ( 24529757) Chin dimples ( 27182965) Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes ( 29221444) Cutaneous squamous cell carcinoma ( 27424798 32041948) HDL cholesterol ( 30275531) Heel bone mineral density ( 30598549) Lung adenocarcinoma ( 28604730) Ovarian cancer ( 19648919) QRS interval (sulfonylurea treatment interaction) ( 27958378) Response to amphetamines ( 22952603) Response to fenofibrate (HDL cholesterol levels) ( 27002377) Squamous cell carcinoma ( 26829030) Waist circumference adjusted for body mass index ( 34021172) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)
Interacting Genes		2 interacting genes: BRCA1 RFK
Entrez ID		54875
HPRD ID		10800
Ensembl ID		ENSG00000044459
Uniprot IDs		B1AMC8 Q9NXG0
PDB IDs
Enriched GO Terms of Interacting Partners?		Histone H2AK127 Ubiquitin Ligase Activity Histone H2AK129 Ubiquitin Ligase Activity BRCA1-BARD1 Complex FMN Biosynthetic Process Positive Regulation Of NAD(P)H Oxidase Activity Riboflavin Kinase Activity Riboflavin Biosynthetic Process Flavin Adenine Dinucleotide Biosynthetic Process BRCA1-B Complex Riboflavin Metabolic Process Small Molecule Biosynthetic Process Nuclear Ubiquitin Ligase Complex Cellular Response To Indole-3-methanol BRCA1-C Complex Response To Indole-3-methanol Negative Regulation Of Centriole Replication BRCA1-A Complex Ubiquitin-modified Histone Reader Activity Negative Regulation Of Centrosome Duplication Lateral Element Negative Regulation Of Intracellular Estrogen Receptor Signaling Pathway Gamma-tubulin Ring Complex DNA Strand Resection Involved In Replication Fork Processing DNA Repair Complex Random Inactivation Of X Chromosome XY Body Negative Regulation Of Gene Expression Via Chromosomal CpG Island Methylation RNA Polymerase Binding Regulation Of Oxidoreductase Activity Negative Regulation Of Fatty Acid Biosynthetic Process Sex-chromosome Dosage Compensation Dosage Compensation By Inactivation Of X Chromosome Regulation Of DNA Damage Checkpoint Protein K6-linked Ubiquitination Regulation Of Centriole Replication Vitamin Metabolic Process Positive Regulation Of Vascular Endothelial Growth Factor Production Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Condensed Chromosome Mitotic G2 DNA Damage Checkpoint Signaling Postreplication Repair Ribonucleoside Monophosphate Biosynthetic Process Negative Regulation Of Reactive Oxygen Species Metabolic Process Homologous Recombination Regulation Of Intracellular Estrogen Receptor Signaling Pathway Negative Regulation Of Fatty Acid Metabolic Process Negative Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Nucleoside Monophosphate Biosynthetic Process Regulation Of Fatty Acid Biosynthetic Process Regulation Of Vascular Endothelial Growth Factor Production
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