QPCTL

Description		glutaminyl-peptide cyclotransferase like
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GO Annotations	Cellular Component	Golgi Membrane Golgi Apparatus Membrane
	Molecular Function	Protein Binding Zinc Ion Binding Glutaminyl-peptide Cyclotransferase Activity Transferase Activity Acyltransferase Activity Metal Ion Binding
	Biological Process	Peptidyl-pyroglutamic Acid Biosynthetic Process, Using Glutaminyl-peptide Cyclotransferase
Pathways
Drugs
Diseases
GWAS		Blood protein levels ( 30072576) BMI (adjusted for smoking behaviour) ( 28443625) BMI in non-smokers ( 28443625) Body mass index ( 20935630 22344219 24861553 25673413 26961502) Body mass index (joint analysis main effects and smoking interaction) ( 28443625) Chronic obstructive pulmonary disease or coronary artery disease (pleiotropy) ( 30940143) Fasting glucose ( 34059833) Fruit consumption ( 32066663) Pancreatic beta-cell glucose sensitivity ( 32944759) Subcutaneous adipose tissue ( 22589738) Waist circumference ( 25673412) Waist-hip ratio ( 25673412)
Interacting Genes		4 interacting genes: APP C3orf52 OLFM4 PTEN
Entrez ID		54814
HPRD ID		08612
Ensembl ID		ENSG00000011478
Uniprot IDs		A0A7I2V5X1 Q9NXS2
PDB IDs		3PB4 3PB6 3PB7 3PB8 3PB9 8XFV 8XGA
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Excitatory Postsynaptic Potential Reproductive Behavior Neuron Projection Organization Modulation Of Excitatory Postsynaptic Potential Acetylcholine Receptor Activator Activity Amyloid-beta Complex PTB Domain Binding Growth Cone Lamellipodium Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Central Nervous System Development Regulation Of Response To Calcium Ion Amylin Binding Endosome To Plasma Membrane Transport Vesicle Adult Behavior Positive Regulation Of Toll Signaling Pathway Positive Regulation Of Endothelin Production Growth Cone Filopodium Lipoprotein Particle Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Regulation Of Nervous System Process Microglia Development Dendritic Spine Positive Regulation Of G Protein-coupled Receptor Internalization Axonogenesis Negative Regulation Of Synaptic Vesicle Clustering Phosphatidylinositol-3,4-bisphosphate 3-phosphatase Activity Negative Regulation Of Keratinocyte Migration Inositol-1,3,4,5-tetrakisphosphate 3-phosphatase Activity Central Nervous System Myelin Maintenance Rhythmic Synaptic Transmission Inositol-1,3,4,5,6-pentakisphosphate 3-phosphatase Activity Locomotory Behavior Positive Regulation Of Proteolysis Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Intermediate-density Lipoprotein Particle Developmental Maturation Axon Midline Choice Point Recognition Positive Regulation Of Amyloid Fibril Formation Cellular Response To Norepinephrine Stimulus Growth Factor Receptor Binding Main Axon Astrocyte Activation Involved In Immune Response Low-density Lipoprotein Particle Mediated Signaling Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase Activity Myelin Sheath Adaxonal Region Regulation Of Cell-substrate Adhesion Negative Regulation Of Wound Healing, Spreading Of Epidermal Cells
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