HAUS6

Description		HAUS augmin like complex subunit 6
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GO Annotations	Cellular Component	Cytoplasm Centrosome Spindle Cytosol Cytoskeleton Microtubule HAUS Complex Mitotic Spindle Microtubule
	Molecular Function	Protein Binding Microtubule Binding
	Biological Process	Microtubule Cytoskeleton Organization Centrosome Cycle Regulation Of Microtubule Nucleation Spindle Assembly Cell Division
Pathways		Regulation of PLK1 Activity at G2/M Transition Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Anchoring of the basal body to the plasma membrane AURKA Activation by TPX2
Drugs
Diseases
GWAS		Mean platelet volume ( 32888494) Platelet count ( 32888494) Prostate cancer ( 29892016) Prostate cancer (early onset) ( 29892016) Pulse pressure ( 30224653 30578418) Type 2 diabetes ( 30297969) Type 2 diabetes or prostate cancer (pleiotropy) ( 33290408)
Interacting Genes		3 interacting genes: APP HAUS8 KDM1A
Entrez ID		54801
HPRD ID		13302
Ensembl ID		ENSG00000147874
Uniprot IDs		Q7Z4H7
PDB IDs		7SQK
Enriched GO Terms of Interacting Partners?		Neuron Maturation Cellular Response To CAMP Acetylcholine Receptor Activator Activity Amyloid-beta Complex PTB Domain Binding Response To Purine-containing Compound Growth Cone Lamellipodium Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Regulation Of Response To Calcium Ion Developmental Maturation Amylin Binding Regulation Of Intrinsic Apoptotic Signaling Pathway Endosome To Plasma Membrane Transport Vesicle Cell Maturation Positive Regulation Of Toll Signaling Pathway Positive Regulation Of Endothelin Production Growth Cone Filopodium Lipoprotein Particle Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Response To CAMP Telomeric Repeat-containing RNA Binding FAD-dependent H3K4me/H3K4me3 Demethylase Activity Negative Regulation Of Transcription Initiation-coupled Chromatin Remodeling Nuclear Microtubule Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Cellular Response To Norepinephrine Stimulus Astrocyte Activation Involved In Immune Response Low-density Lipoprotein Particle Mediated Signaling Protein Demethylase Activity Intermediate-density Lipoprotein Particle Epigenetic Regulation Of Gene Expression Axon Midline Choice Point Recognition Positive Regulation Of Amyloid Fibril Formation Growth Factor Receptor Binding Main Axon MRF Binding Regulation Of Spontaneous Synaptic Transmission Response To Light Stimulus NMDA Selective Glutamate Receptor Signaling Pathway Regulation Of Synapse Structure Or Activity Regulation Of Toll Signaling Pathway Response To Fungicide Guanine Metabolic Process Axon Choice Point Recognition Heparan Sulfate Binding
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