PPEF2

Description		protein phosphatase with EF-hand domain 2
Image		No pdb structure
GO Annotations	Cellular Component	Photoreceptor Outer Segment Photoreceptor Inner Segment Nucleus Cytoplasm Cytosol Cilium Cell Projection
	Molecular Function	Phosphoprotein Phosphatase Activity Protein Serine/threonine Phosphatase Activity Iron Ion Binding Calcium Ion Binding Hydrolase Activity Manganese Ion Binding Protein Serine/threonine Kinase Inhibitor Activity Hsp70 Protein Binding Mitogen-activated Protein Kinase Kinase Kinase Binding Metal Ion Binding Hsp90 Protein Binding
	Biological Process	Protein Dephosphorylation Visual Perception Negative Regulation Of MAPK Cascade Detection Of Stimulus Involved In Sensory Perception Cellular Response To Hydrogen Peroxide Negative Regulation Of Apoptotic Signaling Pathway
Pathways
Drugs
Diseases
GWAS		Hippocampal volume ( 29274321)
Novel Interacting Genes		1 novel interacting genes: MPHOSPH10
Interacting Genes		3 interacting genes: CALM1 CALM2 CALM3
Entrez ID		5470
HPRD ID		03771
Ensembl ID		ENSG00000156194
Uniprot IDs		O14830
PDB IDs
Enriched GO Terms of Interacting Partners?		Transporter Inhibitor Activity Negative Regulation Of Calcium Ion Export Across Plasma Membrane Regulation Of Calcium Ion Export Across Plasma Membrane Adenylate Cyclase Activator Activity Regulation Of Cell Communication By Electrical Coupling Involved In Cardiac Conduction Titin Binding Detection Of Calcium Ion Regulation Of Cell Communication By Electrical Coupling Protein Phosphatase Activator Activity Calyx Of Held Catalytic Complex Regulation Of Cardiac Muscle Contraction By Regulation Of The Release Of Sequestered Calcium Ion Negative Regulation Of Transporter Activity Calcium Channel Complex Calcineurin-mediated Signaling Presynaptic Cytosol Myelin Sheath Regulation Of Cardiac Muscle Contraction By Calcium Ion Signaling Regulation Of Release Of Sequestered Calcium Ion Into Cytosol By Sarcoplasmic Reticulum Negative Regulation Of High Voltage-gated Calcium Channel Activity Negative Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Negative Regulation Of Calcium Ion Transmembrane Transport Spindle Microtubule Presynaptic Endocytosis Substantia Nigra Development Calcium Channel Regulator Activity Sperm Midpiece Negative Regulation Of Calcium Ion Transport G2/M Transition Of Mitotic Cell Cycle Long-term Synaptic Potentiation Sarcomere Cell Cycle G2/M Phase Transition Neural Nucleus Development Negative Regulation Of Cation Transmembrane Transport Protein Serine/threonine Kinase Activator Activity Negative Regulation Of Monoatomic Ion Transmembrane Transport Voltage-gated Potassium Channel Complex Calcium-dependent Protein Binding Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Regulation Of Cardiac Muscle Contraction Regulation Of Monoatomic Ion Transmembrane Transporter Activity Regulation Of Transmembrane Transporter Activity Regulation Of Cytokinesis Negative Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Vesicle-mediated Transport In Synapse Regulation Of Calcium-mediated Signaling Regulation Of Striated Muscle Contraction Negative Regulation Of Monoatomic Ion Transport Positive Regulation Of Sequestering Of Calcium Ion
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