SDK2

Name	sidekick cell adhesion molecule 2
Structure
Interactors	4 interactors: BRCA1 SRPK2 USP7 VMAC
GO Annotations	Cellular Component	Plasma Membrane Membrane Synapse
	Molecular Function	Protein Binding
	Biological Process	Cell Adhesion Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Synapse Assembly Retina Layer Formation Camera-type Eye Photoreceptor Cell Differentiation
Pathways	SDK interactions
GWAS	Hashimoto thyroiditis ( 30284222 ) Liver fibrosis severity in HIV/hepatitis C co-infection ( 27339598 ) Panic disorder ( 19165232 ) Pursuit maintenance gain ( 29064472 ) Response to zileuton treatment in asthma (FEV1 change interaction) ( 26031901 )
Entrez ID	54549
HPRD ID	06239
Ensembl ID	ENSG00000069188
Uniprot IDs	Q58EX2
PDB IDs	1WF5 1WFN 1WFO 1WIS
GO Terms Enriched among Interactors ?	Negative Regulation Of Gene Expression Via Chromosomal CpG Island Methylation P53 Binding Histone H2AK127 Ubiquitin Ligase Activity Negative Regulation Of Small Molecule Metabolic Process Chromatin Remodeling Histone H2AK129 Ubiquitin Ligase Activity Chromosome BRCA1-BARD1 Complex Chromatin Organization BRCA1-B Complex Negative Regulation Of Gene Expression, Epigenetic Nuclear Speck Organization Symbiont-mediated Disruption Of Host Cell PML Body Type III Intermediate Filament Negative Regulation Of Centriole Replication Nuclear Ubiquitin Ligase Complex Cellular Response To Indole-3-methanol BRCA1-C Complex Response To Indole-3-methanol Epigenetic Regulation Of Gene Expression Regulation Of Establishment Of Protein Localization To Chromosome Regulation Of Establishment Of Protein Localization To Telomere Regulation Of Retrograde Transport, Endosome To Golgi BRCA1-A Complex Ubiquitin-modified Histone Reader Activity Regulation Of Small Molecule Metabolic Process R-loop Processing Monoubiquitinated Protein Deubiquitination Negative Regulation Of Centrosome Duplication Protein Modification Process Nuclear Body Lateral Element Negative Regulation Of Intracellular Estrogen Receptor Signaling Pathway Gamma-tubulin Ring Complex DNA Strand Resection Involved In Replication Fork Processing DNA Repair Complex Random Inactivation Of X Chromosome DNA Alkylation Repair Regulation Of Telomere Capping Transcription-coupled Nucleotide-excision Repair XY Body Intracellular Signal Transduction Nuclear Body Organization K48-linked Deubiquitinase Activity RNA Polymerase Binding Negative Regulation Of Gluconeogenesis Negative Regulation Of Fatty Acid Biosynthetic Process Regulation Of DNA Metabolic Process Sex-chromosome Dosage Compensation Dosage Compensation By Inactivation Of X Chromosome