TMX3

Description		thioredoxin related transmembrane protein 3
Image		No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Plasma Membrane Cell Surface Membrane Platelet Alpha Granule Membrane
	Molecular Function	Protein Disulfide Isomerase Activity Protein Binding Protein-disulfide Reductase Activity Isomerase Activity
	Biological Process
Pathways		Platelet degranulation
Drugs
Diseases
GWAS		Attention deficit hyperactivity disorder ( 23728934) Cerebral amyloid deposition in APOEe4 non-carriers (PET imaging) ( 26252872) Suicide in bipolar disorder ( 25917933)
Interacting Genes		5 interacting genes: APP FHL3 FILNC1 OGT UBC
Entrez ID		54495
HPRD ID		15591
Ensembl ID		ENSG00000166479
Uniprot IDs		B4DIE3 Q96JJ7
PDB IDs
Enriched GO Terms of Interacting Partners?		Amyloid-beta Complex Regulation Of ATP Metabolic Process Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Regulation Of Carbohydrate Catabolic Process Regulation Of Glycolytic Process Amylin Binding Regulation Of Purine Nucleotide Metabolic Process Positive Regulation Of Toll Signaling Pathway Protein N-acetylglucosaminyltransferase Complex Negative Regulation Of Non-canonical Inflammasome Complex Assembly Acetylcholine Receptor Activator Activity PTB Domain Binding Regulation Of Synapse Assembly Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Endothelin Production Growth Cone Filopodium Lipoprotein Particle Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Regulation Of Generation Of Precursor Metabolites And Energy Protein O-acetylglucosaminyltransferase Activity Positive Regulation Of Proteolysis Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Intermediate-density Lipoprotein Particle Axon Midline Choice Point Recognition Hemopoiesis Positive Regulation Of Amyloid Fibril Formation Cellular Response To Norepinephrine Stimulus Growth Factor Receptor Binding Main Axon Astrocyte Activation Involved In Immune Response Low-density Lipoprotein Particle Mediated Signaling Positive Regulation Of Transcription From RNA Polymerase II Promoter By Glucose Regulation Of Transcription From RNA Polymerase II Promoter By Glucose Regulation Of Spontaneous Synaptic Transmission NMDA Selective Glutamate Receptor Signaling Pathway Regulation Of Synapse Structure Or Activity Regulation Of Toll Signaling Pathway Non-canonical Inflammasome Complex Assembly Positive Regulation Of Transcription By Glucose Axon Choice Point Recognition Carbon Catabolite Regulation Of Transcription Regulation Of Cell Junction Assembly Heparan Sulfate Binding
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