MIOS

Description		meiosis regulator for oocyte development
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GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Lysosome Lysosomal Membrane Cytosol Membrane Cell Junction GATOR2 Complex
	Molecular Function	Protein Binding Zinc Ion Binding Metal Ion Binding
	Biological Process	Protein-containing Complex Localization Cellular Response To Nutrient Levels Central Nervous System Myelin Formation Cellular Response To Amino Acid Starvation Oligodendrocyte Differentiation Oligodendrocyte Progenitor Proliferation Negative Regulation Of TORC1 Signaling Positive Regulation Of TORC1 Signaling
Pathways		Amino acids regulate mTORC1
Drugs
Diseases
GWAS
Interacting Genes		3 interacting genes: NTAQ1 SESN1 SESN3
Entrez ID		54468
HPRD ID		07898
Ensembl ID		ENSG00000164654
Uniprot IDs		Q9NXC5
PDB IDs		7UHY
Enriched GO Terms of Interacting Partners?		L-leucine Binding Oxidoreductase Activity, Acting On Peroxide As Acceptor Regulation Of Response To Reactive Oxygen Species GATOR2 Complex Cellular Response To Leucine Starvation Cellular Response To L-leucine Response To L-leucine Regulation Of Response To Oxidative Stress Cellular Response To Glucose Starvation Cellular Response To Amino Acid Starvation Response To Amino Acid Starvation Negative Regulation Of TORC1 Signaling Cellular Response To Amino Acid Stimulus Negative Regulation Of TOR Signaling Positive Regulation Of Macroautophagy Regulation Of TORC1 Signaling Response To Amino Acid Protein-N-terminal Glutamine Amidohydrolase Activity Regulation Of TOR Signaling Positive Regulation Of Autophagy Cellular Response To Starvation Protein-N-terminal Asparagine Amidohydrolase Activity Regulation Of Macroautophagy Response To Starvation Cellular Response To Nutrient Levels Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of Autophagy TORC2 Complex Response To Nutrient Levels Hydrolase Activity, Acting On Carbon-nitrogen (but Not Peptide) Bonds, In Linear Amides TORC2 Signaling Oxidoreductase Activity Positive Regulation Of Catabolic Process Negative Regulation Of Intracellular Signal Transduction Cellular Response To Oxygen-containing Compound Regulation Of Insulin Receptor Signaling Pathway Cellular Oxidant Detoxification TOR Signaling Reactive Oxygen Species Metabolic Process Negative Regulation Of Signal Transduction Cellular Detoxification Negative Regulation Of Cell Communication Negative Regulation Of Signaling Cellular Response To Stress
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