DNAJC10

Description		DnaJ heat shock protein family (Hsp40) member C10
Image		No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Lumen Membrane Endoplasmic Reticulum Chaperone Complex
	Molecular Function	ATPase Activator Activity Protein Binding Protein-disulfide Reductase Activity Disulfide Oxidoreductase Activity Oxidoreductase Activity Oxidoreductase Activity, Acting On A Sulfur Group Of Donors, Disulfide As Acceptor Hsp70 Protein Binding Protein-folding Chaperone Binding ATPase Binding Misfolded Protein Binding
	Biological Process	Protein Folding In Endoplasmic Reticulum Response To Endoplasmic Reticulum Stress IRE1-mediated Unfolded Protein Response ERAD Pathway Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress
Pathways
Drugs
Diseases
GWAS		Blood protein levels ( 30072576) Night sleep phenotypes ( 27126917) Pulmonary arterial hypertension ( 29088834) Waist-to-hip circumference ratio (dietary energy interaction) ( 23192594)
Novel Interacting Genes		1 novel interacting genes: ZNF804A
Interacting Genes		4 interacting genes: HSPA5 MAGEA11 PTEN SQSTM1
Entrez ID		54431
HPRD ID		09722
Ensembl ID		ENSG00000077232
Uniprot IDs		Q8IXB1
PDB IDs
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Biosynthetic Process Regulation Of Protein Folding Enzyme Binding Maintenance Of Protein Localization In Endoplasmic Reticulum Regulation Of Cellular Component Organization PERK-mediated Unfolded Protein Response ER Overload Response Regulation Of Protein Ubiquitination Post-translational Protein Targeting To Membrane, Translocation Cerebellum Structural Organization Regulation Of Macromolecule Biosynthetic Process Endoplasmic Reticulum Chaperone Complex Negative Regulation Of PERK-mediated Unfolded Protein Response IRE1-mediated Unfolded Protein Response Regulation Of Protein Modification Process Regulation Of Post-translational Protein Modification Regulation Of Macromolecule Metabolic Process Cerebellar Purkinje Cell Layer Development Ubiquitin Protein Ligase Binding Regulation Of Gene Expression Regulation Of Transcription By RNA Polymerase II Protein Folding In Endoplasmic Reticulum Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of ATF6-mediated Unfolded Protein Response Regulation Of Protein Folding In Endoplasmic Reticulum Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of IRE1-mediated Unfolded Protein Response Locomotor Rhythm Negative Regulation Of Synaptic Vesicle Clustering Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase Activity Myelin Sheath Adaxonal Region Cellular Response To Electrical Stimulus Ubiquitin Ligase Activator Activity Phosphatidylinositol-3,4-bisphosphate 3-phosphatase Activity Spindle Assembly Involved In Female Meiosis Negative Regulation Of Keratinocyte Migration Inositol-1,3,4,5-tetrakisphosphate 3-phosphatase Activity Negative Regulation Of Peptidyl-serine Phosphorylation Regulation Of Synaptic Vesicle Clustering PML Body Postsynaptic Specialization Assembly Negative Regulation Of Wound Healing, Spreading Of Epidermal Cells Neuron-neuron Synaptic Transmission Phosphatidylinositol Phosphate Phosphatase Activity Central Nervous System Myelin Maintenance Negative Regulation Of Cell Size Presynaptic Membrane Organization Schmidt-Lanterman Incisure Rhythmic Synaptic Transmission Anaphase-promoting Complex Binding
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