HAO1

Description		hydroxyacid oxidase 1
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GO Annotations	Cellular Component	Peroxisome Peroxisomal Matrix Cytosol
	Molecular Function	(S)-2-hydroxy-acid Oxidase Activity FMN Binding Oxidoreductase Activity Glyoxylate Oxidase Activity
	Biological Process	Fatty Acid Alpha-oxidation Glycine Biosynthetic Process Response To Oxidative Stress Amino Acid Biosynthetic Process Fatty Acid Oxidation Glycolate Catabolic Process
Pathways		Glyoxylate metabolism and glycine degradation Peroxisomal protein import Peroxisomal protein import
Drugs		N-sulfo-flavin mononucleotide Benzoylformic Acid 3-Decyl-2,5-Dioxo-4-Hydroxy-3-Pyrroline Flavin mononucleotide Phenylpyruvic acid 4-Carboxy-5-(1-Pentyl)Hexylsulfanyl-1,2,3-Triazole 5-(dodecylthio)-1H-1,2,3-triazole-4-carboxylic acid 3-(INDOL-3-YL) LACTATE (2S)-2-HYDROXYOCTANOIC ACID Lumasiran
Diseases
GWAS		Childhood ear infection ( 27182965) Colorectal cancer ( 23263487 24836286 30529582) Colorectal cancer or advanced adenoma ( 30510241) Dentures ( 31235808) Heel bone mineral density ( 30598549) Hip minimal joint space width ( 27701424) Nose morphology ( 29921221) Number of decayed, missing and filled tooth surfaces or use of dentures ( 31235808) Ossification of the posterior longitudinal ligament of the spine ( 25064007) QT interval ( 29213071) Smoking status (heavy vs light) ( 28520984) Systemic lupus erythematosus ( 26502338)
Interacting Genes		1 interacting genes: PEX5
Entrez ID		54363
HPRD ID		05429
Ensembl ID		ENSG00000101323
Uniprot IDs		A8K058 Q9UJM8
PDB IDs		2NZL 2RDT 2RDU 2RDW 2W0U 5QIB 5QIC 5QID 5QIE 5QIF 5QIG 5QIH 6GMB 6GMC 6W44 6W45 6W4C 7M2O 7R4N 7R4O 7R4P
Enriched GO Terms of Interacting Partners?		Protein Import Into Peroxisome Matrix, Translocation Peroxisome Membrane Targeting Sequence Binding Peroxisome Matrix Targeting Signal-1 Binding Peroxisome Targeting Sequence Binding Protein Import Into Peroxisome Matrix, Docking Protein Import Into Peroxisome Membrane Protein Import Into Peroxisome Matrix, Substrate Release Protein Targeting To Peroxisome Protein Import Into Peroxisome Matrix, Receptor Recycling Protein Carrier Chaperone Protein Unfolding Protein Import Into Peroxisome Matrix Pexophagy Peroxisomal Membrane Transport Establishment Of Protein Localization To Peroxisome Cerebral Cortex Neuron Differentiation Receptor Recycling Peroxisome Organization Intracellular Protein Transmembrane Transport Cerebral Cortex Cell Migration Positive Regulation Of Multicellular Organism Growth Very Long-chain Fatty Acid Metabolic Process Forebrain Neuron Differentiation Telencephalon Cell Migration Forebrain Cell Migration Receptor Metabolic Process Peroxisomal Matrix Fatty Acid Beta-oxidation Protein Monoubiquitination Endoplasmic Reticulum Organization Peroxisomal Membrane Regulation Of Multicellular Organism Growth Protein Transmembrane Transport Fatty Acid Oxidation Fatty Acid Catabolic Process Lipid Oxidation Protein Tetramerization Cellular Response To Reactive Oxygen Species Neuromuscular Process Mitochondrial Membrane Organization Peroxisome Lipid Modification Central Nervous System Neuron Differentiation Protein-containing Complex Disassembly Negative Regulation Of Protein-containing Complex Assembly Neuron Migration Macroautophagy Positive Regulation Of Developmental Growth Response To Reactive Oxygen Species Establishment Of Protein Localization To Membrane
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