PNMT

Description		phenylethanolamine N-methyltransferase
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GO Annotations	Cellular Component	Cytosol
	Molecular Function	Phenylethanolamine N-methyltransferase Activity Protein Binding Methyltransferase Activity Transferase Activity
	Biological Process	Methylation Epinephrine Biosynthetic Process Catecholamine Biosynthetic Process
Pathways		Catecholamine biosynthesis
Drugs		S-adenosyl-L-homocysteine 1,2,3,4-Tetrahydro-Isoquinoline-7-Sulfonic Acid Amide 7-Iodo-1,2,3,4-Tetrahydro-Isoquinoline 8,9-Dichloro-2,3,4,5-Tetrahydro-1h-Benzo[C]Azepine CIS-(1R,2S)-2-AMINO-1,2,3,4-TETRAHYDRONAPHTHALEN-1-OL (3R)-3-(FLUOROMETHYL)-7-(THIOMORPHOLIN-4-YLSULFONYL)-1,2,3,4-TETRAHYDROISOQUINOLINE (3R)-N-(4-CHLOROPHENYL)-3-(HYDROXYMETHYL)-1,2,3,4-TETRAHYDROISOQUINOLINE-7-SULFONAMIDE (3R)-3-(FLUOROMETHYL)-N-(3,3,3-TRIFLUOROPROPYL)-1,2,3,4-TETRAHYDROISOQUINOLINE-7-SULFONAMIDE [(3R)-7-NITRO-1,2,3,4-TETRAHYDROISOQUINOLIN-3-YL]METHANOL (1S,4R,9S)-5-(trifluoromethyl)-1,2,3,4-tetrahydro-1,4-methanonaphthalen-9-amine (1R)-2-amino-1-[3-(trifluoromethyl)phenyl]ethanol 7,8-Dichloro-1,2,3,4-tetrahydroisoquinoline N-(4-CHLOROPHENYL)-1,2,3,4-TETRAHYDROISOQUINOLINE-7-SULFONAMIDE TRANS-(1S,2S)-2-AMINO-1,2,3,4-TETRAHYDRONAPHTHALEN-1-OL
Diseases
GWAS		Alcohol consumption ( 31358974) Asthma ( 31619474 31959851) Asthma or allergic disease (pleiotropy) ( 29785011) Bronchial hyperresponsiveness in asthma ( 27439200) Pancreatic ductal adenocarcinoma ( 30541042) Refractive error ( 32231278) Ulcerative colitis ( 20228799 21297633) Urinary metabolites ( 26352407)
Interacting Genes		4 interacting genes: KLHL8 LNX1 TERF1 TERF2IP
Entrez ID		5409
HPRD ID		07176
Ensembl ID		ENSG00000141744
Uniprot IDs		A8MT87 P11086
PDB IDs		1HNN 1N7I 1N7J 1YZ3 2AN3 2AN4 2AN5 2G70 2G71 2G72 2G8N 2OBF 2ONY 2ONZ 2OPB 3HCA 3HCB 3HCC 3HCD 3HCE 3HCF 3KPJ 3KPU 3KPV 3KPW 3KPY 3KQM 3KQO 3KQP 3KQQ 3KQS 3KQT 3KQV 3KQW 3KQY 3KR0 3KR1 3KR2 4DM3 4MIK 4MQ4 6WS1 7TWU 7TX2
Enriched GO Terms of Interacting Partners?		Nuclear Telomere Cap Complex Shelterin Complex G-rich Strand Telomeric DNA Binding Telomere Capping Telomere Maintenance Via Telomerase RNA-templated DNA Biosynthetic Process Telomeric DNA Binding Telomere Maintenance Via Telomere Lengthening Negative Regulation Of Telomere Maintenance Positive Regulation Of Telomere Maintenance DNA Biosynthetic Process Negative Regulation Of Establishment Of Protein Localization To Telomere Negative Regulation Of Establishment Of Protein-containing Complex Localization To Telomere Telomere Maintenance Negative Regulation Of Establishment Of RNA Localization To Telomere Negative Regulation Of Chromosome Organization Positive Regulation Of Chromosome Organization Regulation Of Telomere Maintenance Positive Regulation Of Shelterin Complex Assembly Telomere Organization Negative Regulation Of DNA Metabolic Process Negative Regulation Of Telomeric D-loop Disassembly Negative Regulation Of Telomere Maintenance Via Semi-conservative Replication Negative Regulation Of DNA Recombination At Telomere Chromosome, Telomeric Region Regulation Of Chromosome Organization Regulation Of Establishment Of Protein Localization To Telomere Regulation Of Establishment Of Protein Localization To Chromosome Telomerase Activity Positive Regulation Of DNA Metabolic Process Ankyrin Repeat Binding Protection From Non-homologous End Joining At Telomere Meiotic Telomere Clustering Chromosome Localization To Nuclear Envelope Involved In Homologous Chromosome Segregation Telomere Localization Telomeric D-loop Disassembly Double-stranded Telomeric DNA Binding Chromosome Organization Telomeric Loop Disassembly Protein Localization To Chromosome, Telomeric Region T-circle Formation Nuclear Body Telomere Maintenance In Response To DNA Damage DNA Binding, Bending Synapse Maturation Regulation Of DNA Metabolic Process Negative Regulation Of Telomere Maintenance Via Telomerase Positive Regulation Of Organelle Organization Negative Regulation Of DNA Replication Ubiquitin-dependent Protein Catabolic Process
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