PNMT

Gene Name		phenylethanolamine N-methyltransferase
Image
Gene Ontology Annotations	Cellular Component	Cytosol
	Molecular Function	Phenylethanolamine N-methyltransferase Activity
	Biological Process	Methylation Cellular Nitrogen Compound Metabolic Process Epinephrine Biosynthetic Process Catecholamine Biosynthetic Process Small Molecule Metabolic Process
Pathways		Amine-derived hormones Catecholamine biosynthesis Metabolism of amino acids and derivatives
Drugs		S-Adenosyl-L-Homocysteine 1,2,3,4-Tetrahydro-Isoquinoline-7-Sulfonic Acid Amide 7-Iodo-1,2,3,4-Tetrahydro-Isoquinoline 8,9-Dichloro-2,3,4,5-Tetrahydro-1h-Benzo[C]Azepine CIS-(1R,2S)-2-AMINO-1,2,3,4-TETRAHYDRONAPHTHALEN-1-OL (3R)-3-(FLUOROMETHYL)-7-(THIOMORPHOLIN-4-YLSULFONYL)-1,2,3,4-TETRAHYDROISOQUINOLINE (3R)-N-(4-CHLOROPHENYL)-3-(HYDROXYMETHYL)-1,2,3,4-TETRAHYDROISOQUINOLINE-7-SULFONAMIDE (3R)-3-(FLUOROMETHYL)-N-(3,3,3-TRIFLUOROPROPYL)-1,2,3,4-TETRAHYDROISOQUINOLINE-7-SULFONAMIDE [(3R)-7-NITRO-1,2,3,4-TETRAHYDROISOQUINOLIN-3-YL]METHANOL (1S,4R,9S)-5-(trifluoromethyl)-1,2,3,4-tetrahydro-1,4-methanonaphthalen-9-amine (1R)-2-amino-1-[3-(trifluoromethyl)phenyl]ethanol 7,8-DICHLORO-1,2,3,4-TETRAHYDROISOQUINOLINE N-(4-CHLOROPHENYL)-1,2,3,4-TETRAHYDROISOQUINOLINE-7-SULFONAMIDE TRANS-(1S,2S)-2-AMINO-1,2,3,4-TETRAHYDRONAPHTHALEN-1-OL
Diseases
GWAS		Ulcerative colitis ( 21297633)
Protein-protein Interactions		2 interactors: TERF1 TERF2IP
Entrez ID		5409
HPRD ID		07176
Ensembl ID
Uniprot IDs		P11086
PDB IDs		1HNN 1N7I 1N7J 1YZ3 2AN3 2AN4 2AN5 2G70 2G71 2G72 2G8N 2OBF 2ONY 2ONZ 2OPB 3HCA 3HCB 3HCC 3HCD 3HCE 3HCF 3KPJ 3KPU 3KPV 3KPW 3KPY 3KQM 3KQO 3KQP 3KQQ 3KQS 3KQT 3KQV 3KQW 3KQY 3KR0 3KR1 3KR2 4DM3
Enriched GO Terms of Interacting Partners?		Telomere Maintenance Via Telomerase Negative Regulation Of Telomere Maintenance Regulation Of Telomere Maintenance RNA-dependent DNA Replication Telomere Maintenance Via Telomere Lengthening Telomere Maintenance Negative Regulation Of Chromosome Organization Negative Regulation Of DNA Metabolic Process Regulation Of Chromosome Organization Negative Regulation Of DNA Recombination At Telomere DNA Replication Negative Regulation Of Telomere Maintenance Via Semi-conservative Replication Telomeric Loop Formation Age-dependent Telomere Shortening Telomere Maintenance Via Telomere Shortening Protection From Non-homologous End Joining At Telomere Telomere Capping Negative Regulation Of Telomere Maintenance Via Telomerase Protein Localization To Chromosome, Telomeric Region Replicative Cell Aging Negative Regulation Of Telomerase Activity Regulation Of Nuclear Cell Cycle DNA Replication Regulation Of Telomere Maintenance Via Telomerase Positive Regulation Of Microtubule Polymerization Regulation Of Double-strand Break Repair Via Homologous Recombination Regulation Of Telomerase Activity Regulation Of Organelle Organization Chromosome Organization Negative Regulation Of DNA Recombination Negative Regulation Of DNA Biosynthetic Process DNA Metabolic Process Regulation Of Double-strand Break Repair Regulation Of Microtubule Polymerization Protein Localization To Chromosome Mitotic Spindle Assembly Checkpoint Spindle Assembly Checkpoint Mitotic Spindle Checkpoint Positive Regulation Of Mitotic Nuclear Division Homeostatic Process Negative Regulation Of Chromosome Segregation Regulation Of DNA Biosynthetic Process Spindle Checkpoint Negative Regulation Of DNA Replication Regulation Of Mitotic Sister Chromatid Separation Negative Regulation Of Mitotic Nuclear Division Regulation Of Mitotic Metaphase/anaphase Transition Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of DNA Repair Negative Regulation Of Proteasomal Protein Catabolic Process Regulation Of DNA Recombination
Tagcloud ?		2at aminoethyl aminotetralin analogue analogues benzobicyclo bridge chair conformation conformationally equatorial ethano extra half ki km microm moiety octane phenylethanolamine phenylethylamine planar preferentially probed restricted skeleton steric tetralol vmax