PITX3

Description		paired like homeodomain 3
Image		No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Sequence-specific Double-stranded DNA Binding
	Biological Process	Lens Development In Camera-type Eye Lens Morphogenesis In Camera-type Eye Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Locomotory Behavior Anatomical Structure Morphogenesis Animal Organ Morphogenesis Regulation Of Gene Expression Negative Regulation Of Gliogenesis Midbrain Development Response To Immobilization Stress Response To Cocaine Positive Regulation Of Neuron Apoptotic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Neuron Development Negative Regulation Of Neurogenesis Lens Fiber Cell Differentiation Dopaminergic Neuron Differentiation Response To Methamphetamine Hydrochloride Positive Regulation Of Cell Proliferation In Midbrain Cellular Response To Glial Cell Derived Neurotrophic Factor
Pathways
Drugs
Diseases
GWAS		Atrial fibrillation ( 29892015) Cognitive ability ( 29186694) Cognitive ability (MTAG) ( 29186694) General cognitive ability ( 29844566) Intelligence (MTAG) ( 29326435) Metabolite levels ( 23823483) Refractive error ( 32231278) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
Novel Interacting Genes		1 novel interacting genes: ATXN1
Interacting Genes
Entrez ID		5309
HPRD ID		04051
Ensembl ID		ENSG00000107859
Uniprot IDs		O75364
PDB IDs
Enriched GO Terms of Interacting Partners?		Poly(G) Binding POZ Domain Binding Negative Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Nuclear Inclusion Body Poly(U) RNA Binding Positive Regulation Of Glial Cell Proliferation Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Visual Behavior Visual Learning Regulation Of Glial Cell Proliferation Positive Regulation Of Gliogenesis Excitatory Postsynaptic Potential Social Behavior Insulin-like Growth Factor Receptor Signaling Pathway Lung Alveolus Development Adult Locomotory Behavior Regulation Of Gliogenesis Associative Learning Regulation Of Postsynaptic Membrane Potential Nuclear Export Nuclear Matrix Memory
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