PENK

Description		proenkephalin
Image
GO Annotations	Cellular Component	Extracellular Region Endoplasmic Reticulum Lumen Plasma Membrane Axon Dendrite Cytoplasmic Vesicle Symmetric Synapse Chromaffin Granule Lumen Synaptic Vesicle Lumen Neuronal Cell Body Perikaryon Axon Terminus Cell Body Fiber Neuronal Dense Core Vesicle Lumen
	Molecular Function	Opioid Peptide Activity Neuropeptide Hormone Activity Protein Binding Opioid Receptor Binding Receptor Ligand Activity
	Biological Process	Osteoblast Differentiation Behavioral Fear Response Response To Hypoxia Startle Response Aggressive Behavior Signal Transduction Neuropeptide Signaling Pathway Chemical Synaptic Transmission Sensory Perception Locomotory Behavior Response To Bacterium Response To Toxic Substance Glial Cell Proliferation Transmission Of Nerve Impulse Sensory Perception Of Pain Response To Estradiol Response To Lipopolysaccharide Cellular Response To Oxidative Stress Response To Nicotine Locomotory Exploration Behavior Response To Immobilization Stress G Protein-coupled Opioid Receptor Signaling Pathway Response To Ethanol Response To Calcium Ion General Adaptation Syndrome, Behavioral Process Cellular Response To Vitamin D Cellular Response To CAMP Cellular Response To Transforming Growth Factor Beta Stimulus Response To Epinephrine Cellular Response To Virus Synaptic Signaling Via Neuropeptide Regulation Of Long-term Synaptic Depression Positive Regulation Of Behavioral Fear Response
Pathways		Peptide ligand-binding receptors Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) G alpha (i) signalling events Post-translational protein phosphorylation
Drugs
Diseases
GWAS		Blood protein levels ( 30072576) Height ( 18391951) Problematic alcohol use ( 32451486) Response to selective serotonin reuptake inhibitors and depression ( 27622933) Suicide in bipolar disorder ( 25917933)
Novel Interacting Genes		2 novel interacting genes: ADD3 HSP90AB1
Interacting Genes
Entrez ID		5179
HPRD ID		08837
Ensembl ID		ENSG00000181195
Uniprot IDs		P01210
PDB IDs		1PLW 1PLX 2LWC 5E33 5E3A 8JGF 8JGG
Enriched GO Terms of Interacting Partners?		Actin Filament Capping Positive Regulation Of Vasoconstriction Barbed-end Actin Filament Capping Axonal Growth Cone Chaperone-mediated Protein Complex Assembly Dynein Axonemal Particle Protein Phosphatase Activator Activity ATP-dependent Protein Binding COP9 Signalosome Telomere Maintenance Via Telomere Lengthening HSP90-CDC37 Chaperone Complex Protein Kinase Regulator Activity Histone Methyltransferase Binding RNA-templated DNA Biosynthetic Process Adhesion Of Symbiont To Host Nitric-oxide Synthase Regulator Activity MHC Class II Protein Complex Binding Response To Interleukin-4 Adhesion Of Symbiont To Host Cell Peptide Binding Telomere Maintenance Via Telomerase Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Dendritic Growth Cone TPR Domain Binding Receptor Ligand Inhibitor Activity Protein Folding Chaperone Complex Cellular Response To Interleukin-4 Aryl Hydrocarbon Receptor Complex Disordered Domain Specific Binding Virion Attachment To Host Cell ATP-dependent Protein Folding Chaperone DNA Polymerase Binding Positive Regulation Of Protein Localization To Cell Surface Telomerase Holoenzyme Complex Assembly Negative Regulation Of Actin Filament Depolymerization Regulation Of Protein Localization To Cell Surface Positive Regulation Of Nitric Oxide Biosynthetic Process Positive Regulation Of Nitric Oxide Metabolic Process Tau Protein Binding Placenta Development Regulation Of Actin Filament Depolymerization Condensed Nuclear Chromosome Protein Kinase C Binding Negative Regulation Of Actin Filament Polymerization Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Cellular Response To Heat Brush Border Regulation Of Vasoconstriction Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Proteasomal Protein Catabolic Process
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