PDE6B

Description		phosphodiesterase 6B
Image		No pdb structure
GO Annotations	Cellular Component	Photoreceptor Outer Segment Plasma Membrane Membrane Photoreceptor Outer Segment Membrane Cell Projection Photoreceptor Disc Membrane
	Molecular Function	3',5'-cyclic-nucleotide Phosphodiesterase Activity 3',5'-cyclic-AMP Phosphodiesterase Activity Phosphoric Diester Hydrolase Activity Hydrolase Activity Metal Ion Binding 3',5'-cyclic-GMP Phosphodiesterase Activity
	Biological Process	Signal Transduction Visual Perception Phototransduction, Visible Light Detection Of Light Stimulus Entrainment Of Circadian Clock By Photoperiod Retina Development In Camera-type Eye Negative Regulation Of CAMP/PKA Signal Transduction Retinal Cell Apoptotic Process
Pathways		Activation of the phototransduction cascade Activation of the phototransduction cascade Inactivation, recovery and regulation of the phototransduction cascade Ca2+ pathway Ca2+ pathway
Drugs		Caffeine Trapidil
Diseases		Congenital stationary night blindness (CSNB), including: CSNB type 1 (CSNB1); CSNB type 2 (CSNB2); CSNB autosomal dominant (CSNBAD); Oguchi disease/ CSNB Oguchi type (CSNBO) Retinitis pigmentosa (RP)
GWAS
Novel Interacting Genes		2 novel interacting genes: GLA THTPA
Interacting Genes
Entrez ID		5158
HPRD ID		01571
Ensembl ID		ENSG00000133256
Uniprot IDs		B4DHV7 P35913
PDB IDs
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Nitric-oxide Synthase Activity Alpha-galactosidase Activity Thiamine Triphosphate Phosphatase Activity Thiamine Diphosphate Metabolic Process Thiamine Diphosphate Biosynthetic Process Thiamine Metabolic Process Glycosylceramide Catabolic Process Regulation Of Nitric-oxide Synthase Activity Glycoside Catabolic Process Negative Regulation Of Oxidoreductase Activity Thiamine-containing Compound Metabolic Process Glycosylceramide Metabolic Process Glycosphingolipid Catabolic Process Ceramide Catabolic Process Negative Regulation Of Nitric Oxide Biosynthetic Process Regulation Of Oxidoreductase Activity Glycolipid Catabolic Process Hydrolase Activity, Hydrolyzing O-glycosyl Compounds Vitamin Metabolic Process Sphingolipid Catabolic Process Pyrimidine-containing Compound Biosynthetic Process Membrane Lipid Catabolic Process Glycosphingolipid Metabolic Process Oligosaccharide Metabolic Process Regulation Of Nitric Oxide Biosynthetic Process Regulation Of Nitric Oxide Metabolic Process Hydrolase Activity, Acting On Glycosyl Bonds Pyrimidine-containing Compound Metabolic Process Hydrolase Activity Glycolipid Metabolic Process Ceramide Metabolic Process Azurophil Granule Lumen Lysosomal Lumen Sulfur Compound Biosynthetic Process Dephosphorylation Sphingolipid Metabolic Process Negative Regulation Of Catalytic Activity Carbohydrate Derivative Catabolic Process Membrane Lipid Metabolic Process Magnesium Ion Binding
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