BIN2

Description		bridging integrator 2
Image
GO Annotations	Cellular Component	Phagocytic Cup Podosome Extracellular Region Cytoplasm Plasma Membrane Cell Cortex Membrane Secretory Granule Lumen Cell Projection Anchoring Junction Ficolin-1-rich Granule Lumen
	Molecular Function	Protein Binding Phospholipid Binding
	Biological Process	Phagocytosis, Engulfment Cell Chemotaxis Podosome Assembly Plasma Membrane Tubulation
Pathways		Neutrophil degranulation Signaling by membrane-tethered fusions of PDGFRA or PDGFRB
Drugs
Diseases
GWAS		Aging (time to death) ( 21782286) Basophil count ( 32888494) Basophil percentage of white cells ( 32888494) Mean platelet volume ( 27863252 32888494) Platelet count ( 32888494)
Novel Interacting Genes		1 novel interacting genes: FAM3B
Interacting Genes		5 interacting genes: APPBP2 CEBPA POT1 TERF1 TINF2
Entrez ID		51411
HPRD ID		05805
Ensembl ID		ENSG00000110934
Uniprot IDs		Q9UBW5
PDB IDs		4AVM 4I1Q
Enriched GO Terms of Interacting Partners?		Shelterin Complex Nuclear Telomere Cap Complex Telomere Capping Negative Regulation Of Telomere Maintenance Via Telomerase Telomeric DNA Binding Negative Regulation Of DNA Biosynthetic Process Negative Regulation Of Telomere Maintenance Via Telomere Lengthening Negative Regulation Of Telomere Maintenance Regulation Of Telomere Maintenance Via Telomerase Regulation Of Telomere Maintenance Via Telomere Lengthening Telomere Assembly Positive Regulation Of Telomere Maintenance Negative Regulation Of Chromosome Organization Regulation Of DNA Biosynthetic Process Telomeric D-loop Disassembly Telomere Maintenance Positive Regulation Of Chromosome Organization G-rich Strand Telomeric DNA Binding Regulation Of Telomere Maintenance Telomeric Loop Disassembly Telomere Organization Negative Regulation Of DNA Metabolic Process Chromosome, Telomeric Region Telomere Maintenance Via Telomerase RNA-templated DNA Biosynthetic Process Telomere Maintenance Via Telomere Lengthening Regulation Of Chromosome Organization Positive Regulation Of DNA Metabolic Process Chromosome Organization RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Negative Regulation Of Establishment Of Protein Localization To Telomere Negative Regulation Of Establishment Of Protein-containing Complex Localization To Telomere Negative Regulation Of Establishment Of RNA Localization To Telomere Positive Regulation Of Shelterin Complex Assembly Positive Regulation Of DNA Strand Elongation Positive Regulation Of Telomeric D-loop Disassembly G-rich Single-stranded DNA Binding DNA Biosynthetic Process Regulation Of DNA Metabolic Process Positive Regulation Of Organelle Organization Response To Vitamin B2 C/EBP Complex Negative Regulation Of Telomeric D-loop Disassembly Negative Regulation Of Telomere Maintenance Via Semi-conservative Replication Positive Regulation Of Telomeric Loop Disassembly Perinucleolar Chromocenter Negative Regulation Of Nucleobase-containing Compound Metabolic Process Nuclear Matrix CHOP-C/EBP Complex 8-hydroxy-2'-deoxyguanosine DNA Binding
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