PDE3A

Gene Name		phosphodiesterase 3A, cGMP-inhibited
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Gene Ontology Annotations	Cellular Component	Cytosol Integral Component Of Membrane
	Molecular Function	3',5'-cyclic-AMP Phosphodiesterase Activity CGMP-inhibited Cyclic-nucleotide Phosphodiesterase Activity CAMP Binding Metal Ion Binding
	Biological Process	Oocyte Maturation CAMP Catabolic Process Lipid Metabolic Process Blood Coagulation Diterpenoid Metabolic Process CAMP-mediated Signaling CGMP-mediated Signaling Regulation Of Meiosis Response To Drug Negative Regulation Of Apoptotic Process Negative Regulation Of Vascular Permeability Positive Regulation Of Vascular Permeability Response To CAMP Positive Regulation Of Oocyte Development Cellular Response To CGMP Cellular Response To Transforming Growth Factor Beta Stimulus
Pathways		Signaling by GPCR GPCR downstream signaling Platelet homeostasis G alpha (s) signalling events Nitric oxide stimulates guanylate cyclase cGMP effects
Drugs		Milrinone Anagrelide Theophylline Levosimendan Cilostazol Aminophylline Oxtriphylline Amrinone Enoximone Ibudilast Tofisopam
Diseases
GWAS		Adiponectin levels ( 22479202) Aortic root size ( 19584346) HDL cholesterol ( 20686565) Height ( 18391951) Male infertility ( 19478329) QT interval ( 20031603) Response to TNF-alpha inhibitors in rheumatoid arthritis ( 22569225)
Protein-protein Interactions		1 interactors: YWHAQ
Entrez ID		5139
HPRD ID		00441
Ensembl ID		ENSG00000172572
Uniprot IDs		Q14432
PDB IDs		1LRC
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Substantia Nigra Development Neural Nucleus Development Positive Regulation Of Mitochondrion Organization Midbrain Development Regulation Of Mitochondrion Organization
Tagcloud ?		acth adrenal adrenocortical adrenocorticotropin belongs biosynthesis camp confers cortisol cyp17a1 dbhs exoribonuclease export facilitating glucocorticoid h295r isoforms nono p54nrb pde11a pde2a pde3b pde4a pde4d phosphodiesterase select splicing xrn2