PDE3A

Description		phosphodiesterase 3A
Image
GO Annotations	Cellular Component	Cytoplasm Cytosol Membrane
	Molecular Function	3',5'-cyclic-nucleotide Phosphodiesterase Activity 3',5'-cyclic-AMP Phosphodiesterase Activity 3',5'-cGMP-inhibited Cyclic-nucleotide Phosphodiesterase Activity Protein Binding Phosphoric Diester Hydrolase Activity Hydrolase Activity Nuclear Estrogen Receptor Activity Metal Ion Binding 3',5'-cyclic-GMP Phosphodiesterase Activity Estrogen Binding
	Biological Process	Oocyte Maturation Lipid Metabolic Process Signal Transduction G Protein-coupled Receptor Signaling Pathway Response To Xenobiotic Stimulus CGMP-mediated Signaling Nuclear Receptor-mediated Steroid Hormone Signaling Pathway Regulation Of Meiotic Nuclear Division Negative Regulation Of Apoptotic Process Negative Regulation Of Vascular Permeability Positive Regulation Of Vascular Permeability Oocyte Development Positive Regulation Of Oocyte Development Regulation Of Ribonuclease Activity Cellular Response To CGMP Cellular Response To Transforming Growth Factor Beta Stimulus Apoptotic Signaling Pathway Negative Regulation Of Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Negative Regulation Of CAMP/PKA Signal Transduction
Pathways		G alpha (s) signalling events
Drugs		Caffeine Milrinone Anagrelide Theophylline Levosimendan Cilostazol Aminophylline Oxtriphylline Amrinone Enoximone Ibudilast Tofisopam Trapidil
Diseases
GWAS		Adiponectin levels ( 31178129 22479202) Aortic root size ( 19584346) Apolipoprotein A1 levels ( 32203549) Appendicular lean mass ( 33097823) Aspartate aminotransferase levels ( 33547301) Body mass index and HDL-C (pairwise) ( 33619380) Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes ( 29221444) Coronary heart disease x type 2 diabetes interaction ( 32541925) Degraded stimulus continuous performance test score ( 31596458) Diastolic blood pressure ( 26390057 27618452 30487518 28135244 28739976) Diastolic blood pressure (cigarette smoking interaction) ( 29455858) Diverticular disease ( 30177863) Fasting insulin ( 34059833) Gut microbiota relative abundance (Coprococcus) ( 33208821) HDL cholesterol ( 20686565 24097068) HDL cholesterol levels ( 28334899 32203549 30698716) HDL cholesterol levels in current drinkers ( 30698716) HDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) HDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Height ( 18391951 28552196 31562340 29782485) Hypertension ( 30487518) Lung adenocarcinoma ( 28604730) Male infertility ( 19478329) Mean arterial pressure ( 30487518) Myocardial infarction ( 33532862) PR interval ( 32439900) Pulse pressure ( 30224653 28135244 30578418) QT interval ( 20031603) Refractive error ( 32231278) Response to platinum-based chemotherapy (carboplatin) ( 21844884) Response to TNF-alpha inhibitors in rheumatoid arthritis ( 22569225) Resting heart rate ( 29769521 27798624) Spherical equivalent or myopia (age of diagnosis) ( 29808027) Systolic blood pressure ( 27618452 28739976 28135244) Systolic blood pressure (alcohol consumption interaction) ( 24376456) Systolic blood pressure (cigarette smoking interaction) ( 29455858) Triglyceride levels ( 32203549 30698716) Triglyceride levels x long total sleep time interaction (2df test) ( 31719535) Waist circumference adjusted for body mass index ( 34021172) White blood cell count ( 32888494)
Interacting Genes		4 interacting genes: AKT1 PRKACA USP7 YWHAQ
Entrez ID		5139
HPRD ID		00441
Ensembl ID		ENSG00000172572
Uniprot IDs		Q14432
PDB IDs		7EG0 7EG1 7EG4 7KWE 7L27 7L28 7L29 7LRC 7LRD
Enriched GO Terms of Interacting Partners?		Negative Regulation Of TOR Signaling TOR Signaling Negative Regulation Of TORC1 Signaling Regulation Of TORC1 Signaling Regulation Of Glucose Metabolic Process TORC1 Signaling Negative Regulation Of Small Molecule Metabolic Process Vascular Endothelial Cell Response To Laminar Fluid Shear Stress Regulation Of TOR Signaling Vascular Endothelial Cell Response To Fluid Shear Stress Regulation Of Proteasomal Protein Catabolic Process Cellular Response To Laminar Fluid Shear Stress Response To Laminar Fluid Shear Stress Positive Regulation Of Cholesterol Biosynthetic Process Cellular Response To Nutrient Levels Protein Serine/threonine/tyrosine Kinase Activity Positive Regulation Of Cholesterol Metabolic Process Regulation Of Cholesterol Biosynthetic Process 14-3-3 Protein Binding Cellular Response To Fluid Shear Stress Positive Regulation Of Steroid Biosynthetic Process Regulation Of Small Molecule Metabolic Process Peptidyl-serine Phosphorylation Regulation Of Protein Catabolic Process Regulation Of Autophagy Positive Regulation Of Steroid Metabolic Process Response To Fluid Shear Stress Regulation Of Proteolysis Negative Regulation Of Catabolic Process Positive Regulation Of Glucose Metabolic Process Regulation Of Cholesterol Metabolic Process Regulation Of Monoatomic Ion Transport Regulation Of Gluconeogenesis Regulation Of Transport Regulation Of Protein Maturation Response To Nutrient Levels Regulation Of Cellular Localization Intracellular Signal Transduction Regulation Of Vesicle-mediated Transport Regulation Of Steroid Biosynthetic Process Response To Heat Positive Regulation Of Lipid Biosynthetic Process Negative Regulation Of Autophagy Regulation Of TRNA Methylation Regulation Of Steroid Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Transmembrane Transport Negative Regulation Of Biosynthetic Process Regulation Of Signal Transduction By P53 Class Mediator Negative Regulation Of Intracellular Signal Transduction
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