SPTBN5

Description		spectrin beta, non-erythrocytic 5
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Cytoskeleton Microtubule Associated Complex Plasma Membrane Spectrin Membrane Cell Junction Cortical Cytoskeleton Cortical Actin Cytoskeleton Photoreceptor Connecting Cilium Cell Projection Organelle Apical Cortex Photoreceptor Disc Membrane Plasma Membrane Bounded Cell Projection
	Molecular Function	Opsin Binding Actin Binding Cytoskeletal Protein Binding Kinesin Binding Spectrin Binding Myosin Tail Binding Dynactin Binding Identical Protein Binding Dynein Intermediate Chain Binding Actin Filament Binding
	Biological Process	Golgi Organization Lysosomal Transport Actin Cytoskeleton Organization Actin Filament Capping
Pathways		NCAM signaling for neurite out-growth NCAM signaling for neurite out-growth Interaction between L1 and Ankyrins Interaction between L1 and Ankyrins RAF/MAP kinase cascade COPI-mediated anterograde transport
Drugs
Diseases
GWAS		Waist circumference adjusted for body mass index ( 28552196 34021172) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172) Waist-to-hip ratio adjusted for BMI (additive genetic model) ( 30778226)
Novel Interacting Genes		2 novel interacting genes: FBN1 TCF12
Interacting Genes		2 interacting genes: MTDH RNF10
Entrez ID		51332
HPRD ID		10438
Ensembl ID		ENSG00000137877
Uniprot IDs		Q9NRC6
PDB IDs
Enriched GO Terms of Interacting Partners?		Protein Kinase A Signaling Sequestering Of Extracellular Ligand From Receptor Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Metabolic Process Gene Expression Sequestering Of BMP In Extracellular Matrix Positive Regulation Of Response To Food Sequestering Of TGFbeta In Extracellular Matrix Regulation Of Multicellular Organismal Development Extracellular Negative Regulation Of Signal Transduction Response To Peptide Hormone Positive Regulation Of Appetite Regulation Of Osteoclast Development Post-embryonic Eye Morphogenesis Cellular Response To Insulin-like Growth Factor Stimulus Negative Regulation Of Osteoclast Development Negative Regulation Of Cell Development Extracellular Matrix Constituent Conferring Elasticity Regulation Of Cell Differentiation Activation Of Protein Kinase A Activity Regulation Of Developmental Process Transcription Cis-regulatory Region Binding HMG Box Domain Binding Response To Gonadotropin-releasing Hormone CAMP Response Element Binding Ribosome-associated Ubiquitin-dependent Protein Catabolic Process Postsynapse To Nucleus Signaling Pathway Negative Regulation Of Schwann Cell Proliferation Extrinsic Component Of Postsynaptic Density Membrane Intercellular Canaliculus Microfibril Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Regulation Of Response To Food Negative Regulation Of Glial Cell Proliferation Positive Regulation Of RNA Metabolic Process Positive Regulation Of Myelination Regulation Of Appetite Positive Regulation Of Nucleobase-containing Compound Metabolic Process Embryonic Eye Morphogenesis Regulation Of Primary Metabolic Process Cell Adhesion Mediated By Integrin BHLH Transcription Factor Binding Negative Regulation Of Osteoclast Differentiation Response To Hormone NF-kappaB Binding
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