RAPGEFL1

Description		Rap guanine nucleotide exchange factor like 1
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GO Annotations	Cellular Component	Plasma Membrane Membrane
	Molecular Function	Guanyl-nucleotide Exchange Factor Activity
	Biological Process	G Protein-coupled Receptor Signaling Pathway Small GTPase-mediated Signal Transduction Ras Protein Signal Transduction Nervous System Development
Pathways
Drugs
Diseases
GWAS		Asthma ( 31619474) HDL cholesterol levels ( 32203549) Monocyte percentage of white cells ( 32888494) White blood cell count ( 32888494)
Novel Interacting Genes		1 novel interacting genes: RAB5C
Interacting Genes		2 interacting genes: APP MLH1
Entrez ID		51195
HPRD ID		17954
Ensembl ID		ENSG00000108352
Uniprot IDs		A0A087WVW6 B4DGK9 F5H2D5 Q9UHV5
PDB IDs		2DHZ
Enriched GO Terms of Interacting Partners?		Acetylcholine Receptor Activator Activity Amyloid-beta Complex PTB Domain Binding Growth Cone Lamellipodium Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Regulation Of Response To Calcium Ion Early Endosome Membrane Cell Activation Involved In Immune Response Amylin Binding Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Toll Signaling Pathway Positive Regulation Of Endothelin Production Growth Cone Filopodium Lipoprotein Particle Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Meiotic Spindle Midzone Assembly Meiotic Metaphase Chromosome Alignment Male Meiosis Chromosome Segregation MutLalpha Complex Chiasma Late Recombination Nodule Meiotic Metaphase I Homologous Chromosome Alignment Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Intermediate-density Lipoprotein Particle Axon Midline Choice Point Recognition Positive Regulation Of Amyloid Fibril Formation Cellular Response To Norepinephrine Stimulus Growth Factor Receptor Binding Main Axon Astrocyte Activation Involved In Immune Response Low-density Lipoprotein Particle Mediated Signaling Guanine/thymine Mispair Binding Homologous Chromosome Segregation Female Meiosis Chromosome Segregation Mismatch Repair Complex Negative Regulation Of Mitotic Recombination Regulation Of Spontaneous Synaptic Transmission NMDA Selective Glutamate Receptor Signaling Pathway Regulation Of Synapse Structure Or Activity Early Endosome Regulation Of Toll Signaling Pathway Regulation Of Endocytosis Positive Regulation Of Isotype Switching To IgA Isotypes Axon Choice Point Recognition MutSalpha Complex Binding
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