PCK2

Description		phosphoenolpyruvate carboxykinase 2, mitochondrial
Image		No pdb structure
GO Annotations	Cellular Component	Mitochondrion Mitochondrial Matrix
	Molecular Function	Nucleotide Binding Phosphoenolpyruvate Carboxykinase Activity Phosphoenolpyruvate Carboxykinase (GTP) Activity Protein Binding GTP Binding Lyase Activity Carboxy-lyase Activity Purine Nucleotide Binding Manganese Ion Binding Metal Ion Binding
	Biological Process	Gluconeogenesis Oxaloacetate Metabolic Process Propionate Catabolic Process Positive Regulation Of Insulin Secretion Response To Lipopolysaccharide Cellular Response To Insulin Stimulus Response To Starvation Glycerol Biosynthetic Process From Pyruvate Hepatocyte Differentiation Cellular Response To Glucose Stimulus Cellular Response To Tumor Necrosis Factor Response To Dexamethasone Cellular Response To Dexamethasone Stimulus
Pathways		Gluconeogenesis
Drugs
Diseases
GWAS		Liver fibrosis and steatohepatitis severity (MRI cT1 measure) ( 32247823)
Interacting Genes		3 interacting genes: APP EP300 SMAD3
Entrez ID		5106
HPRD ID		02026
Ensembl ID		ENSG00000100889
Uniprot IDs		A0A384MTT2 Q16822
PDB IDs
Enriched GO Terms of Interacting Partners?		Regulation Of Protein Localization To Nucleus Positive Regulation Of Gene Expression, Epigenetic Developmental Growth Positive Regulation Of Nitric Oxide Biosynthetic Process Negative Regulation Of MiRNA Transcription Positive Regulation Of Establishment Of Protein Localization Regulation Of Establishment Of Protein Localization Regulation Of Glycolytic Process Regulation Of Protein Transport Chromatin Binding Positive Regulation Of Protein Localization Positive Regulation Of Nitric Oxide Metabolic Process Positive Regulation Of Protein Transport Somitogenesis Segmentation Nuclear Receptor Binding Positive Regulation Of Protein Import Into Nucleus Transcription Coactivator Binding Myeloid Cell Development Regulation Of Nitric Oxide Biosynthetic Process Regulation Of Carbohydrate Catabolic Process Positive Regulation Of Interleukin-1 Beta Production Leukocyte Activation Regulation Of Nitric Oxide Metabolic Process Regulation Of Protein Import Into Nucleus Positive Regulation Of Nucleocytoplasmic Transport Positive Regulation Of Interleukin-1 Production Cell Activation Regulation Of ATP Metabolic Process Regulation Of MiRNA Transcription Regulation Of Purine Nucleotide Metabolic Process Chromatin DNA Binding Regulation Of MiRNA Metabolic Process Positive Regulation Of Intracellular Protein Transport Regulation Of Interleukin-1 Beta Production Positive Regulation Of Protein Localization To Nucleus Amyloid-beta Complex Apoptotic Process Regulation Of Defense Response Growth Cone Lamellipodium Cellular Response To Oxygen-containing Compound Regulation Of Immune Response Regulation Of Response To Calcium Ion Regulation Of Interleukin-1 Production Negative Regulation Of Transcription By RNA Polymerase II Intracellular Signaling Cassette Amylin Binding Programmed Cell Death Positive Regulation Of Toll Signaling Pathway Cell Development
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