PCDH8

Description		protocadherin 8
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GO Annotations	Cellular Component	Plasma Membrane Membrane Dendrite Presynaptic Membrane Cell Projection Synapse Postsynaptic Membrane Schaffer Collateral - CA1 Synapse Glutamatergic Synapse
	Molecular Function	Calcium Ion Binding Cell Adhesion Molecule Binding
	Biological Process	Somitogenesis Cell Adhesion Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Cell-cell Signaling Chemical Synaptic Transmission Morphogenesis Of Embryonic Epithelium Modulation Of Chemical Synaptic Transmission Cell-cell Adhesion Regulation Of Synaptic Membrane Adhesion
Pathways
Drugs
Diseases
GWAS		Airflow obstruction ( 22837378) Cerebrospinal P-tau181p levels ( 28247064) Immune response to anthrax vaccine ( 22658931) Metabolite levels ( 23823483)
Novel Interacting Genes		1 novel interacting genes: GRIN2A
Interacting Genes		2 interacting genes: BTRC UBQLN4
Entrez ID		5100
HPRD ID		04660
Ensembl ID		ENSG00000136099
Uniprot IDs		O95206
PDB IDs		6VFV
Enriched GO Terms of Interacting Partners?		Regulation Of Protein Catabolic Process Negative Regulation Of Catabolic Process Negative Regulation Of Autophagy Macromolecule Catabolic Process Protein Phosphorylated Amino Acid Binding Nuclear Proteasome Complex Regulation Of Proteasomal Protein Catabolic Process Directional Locomotion Negative Regulation Of Autophagosome Maturation Regulation Of Protein Metabolic Process Cytosolic Proteasome Complex NMDA Selective Glutamate Receptor Complex Glutamate-gated Calcium Ion Channel Activity NMDA Glutamate Receptor Activity Sleep Catabolic Process Regulation Of Proteolysis Regulation Of Autophagy Excitatory Chemical Synaptic Transmission K48-linked Polyubiquitin Modification-dependent Protein Binding Serotonin Metabolic Process Ubiquitin Ligase Activator Activity Negative Regulation Of Macromolecule Metabolic Process Startle Response Branching Involved In Mammary Gland Duct Morphogenesis Modification-dependent Protein Catabolic Process Mammary Gland Epithelial Cell Proliferation Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of T Cell Receptor Signaling Pathway Regulation Of Autophagosome Maturation Positive Regulation Of Circadian Rhythm Protein Catabolic Process Protein Localization To Postsynaptic Membrane Positive Regulation Of Excitatory Postsynaptic Potential Ligand-gated Monoatomic Ion Channel Activity Response To Amphetamine Negative Regulation Of Metabolic Process Positive Regulation Of Synaptic Transmission, Glutamatergic Ionotropic Glutamate Receptor Signaling Pathway Dopamine Metabolic Process Protein Metabolic Process Positive Regulation Of Antigen Receptor-mediated Signaling Pathway Proteolysis Involved In Protein Catabolic Process Non-canonical NF-kappaB Signal Transduction Negative Regulation Of T Cell Receptor Signaling Pathway Negative Regulation Of Double-strand Break Repair Via Homologous Recombination Protein Localization To Postsynapse Monoatomic Cation Channel Activity Ligand-gated Ion Channel Signaling Pathway Intracellular Signaling Cassette
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